正交实验优选关木通碱制工艺  

Optimization of Processing Conditions of Manchurian Dutchmanspipe Stem Processed with Alkali by Orthogonal Experiment

作　　者：张春杰[1] 曹蕊[2] 张春红[1] 

机构地区：[1]包头医学院,内蒙古包头014060 [2]吉林农业大学中药材学院

出　　处：《包头医学院学报》2012年第4期4-6,共3页Journal of Baotou Medical College

基　　金：吉林农业大学博士启动基金(NO.2007011)

摘　　要：目的:优化碱制关木通的工艺条件。方法:以马兜铃总酸去除率为考察指标,采用正交设计法考察NaHCO3浓度、炮制时间及炮制次数对关木通中马兜铃酸的影响。结果:最佳工艺是用浓度0.5 mol/L的NaHCO3溶液浸泡1次、时间为24 h。结论:本实验为进一步研究关木通的炮制减毒工艺提供了参考依据。Objective： To optimize the process conditions of Manchurian Dutchmanspipe Stem processed with alkali. Meth- ods ： With the strainaway rate of total aristolochic acid as evaluation index, orthogonal experiment was used to investigate the in- fluence of NaHCO3 concentration, processing time and processing times on total aristolochic acid. Results： The optimum process conditions were as follows： soaked 1 time with 0.5 mol/L NaHCO3 solution, and soaking for 24 hours. Conclusion： The study provided a reference for the further research attenuation process conditions of Manchurian Dutchmanspipe Stem.

关 键 词：正交试验 关木通 马兜铃酸 减毒 碱制 

分 类 号：R283[医药卫生—中药学]