Mannich反应合成新型4-甲基-2-芳胺甲基苯酚类化合物  

Synthesis of novel 2-arylaminomethyl-4-methyl phenols by Mannich reaction

作　　者：夏赞稳[1] 颜林[1] 唐子龙[1,2] 唐瑞仁[3] 李丽[1] 黄勇[1] 刘汉文[1,2] 

机构地区：[1]湖南科技大学化学化工学院,湖南湘潭411201 [2]理论化学与分子模拟省部共建教育部重点实验室,湖南湘潭411201 [3]中南大学化学化工学院,湖南长沙410083

出　　处：《湖南科技大学学报（自然科学版）》2012年第3期102-106,共5页Journal of Hunan University of Science And Technology：Natural Science Edition

基　　金：国家自然科学基金(21042011);湖南省教育厅重点项目(10A034);湖南省博士后基金(2010RS4033);理论化学教育部重点实验室开放基金课题(LKF0906)

摘　　要：以对甲酚、多聚甲醛和取代苯胺为原料,利用Mannich反应法和"分步反应法"合成了一系列新型4-甲基-2-芳胺甲基苯酚,实验结果表明除苯环上没有取代基的产物(4a)外,其余产物经Mannich反应合成的产率均高于经"分步法"合成的产率.特别是经Mannich反应合成目标产物,减少了实验步骤、溶剂的使用和废物的排放,从而减少了环境污染,符合绿色化学的要求.用IR,1H NMR,13C NMR等对产物的结构进行了确证.A series of novel 2 - arylaminomethyl - 4 - methyl phenols were synthesized using p - cresol, paraformaldehyde and substituted anilines as materials by ＂fractional step methond＂ and Mannich reaction, respectively. The results showed the yields of the products prepared by Mannich reaction except for compound 4a without substituent on the benzen ring are higher than those obtained by ＂fractional step methond＂. In particular, the procedure through Mannich reaction is greatly simplified, and reduce the use of solvent and the release of the waste substance, and hence reduce the enviroment pollution. It is a green procedure for the preparation of this kind of products. The structures of the target compounds are characterized by IR, 1H NMR and 13 CNMR spectra.

关 键 词：分步法 MANNICH反应 4-甲基-2-芳胺甲基苯酚 合成 

分 类 号：O621[理学—有机化学]