安络化纤丸预防大鼠酒精性脂肪肝形成的作用  

Prevention effects of Anluohuaxianwan on alcoholic fatty liver in rats

作　　者：相妍笑[1] 娄海燕[1] 王菊英[1] 于晓彦[1] 冯一民[1] 张岫美[1] 

机构地区：[1]山东大学医学院药理学研究所,山东济南250012

出　　处：《中国生化药物杂志》2012年第5期537-539,543,共4页Chinese Journal of Biochemical Pharmaceutics

基　　金：山东省科技攻关计划(2008GG2NS02014)

摘　　要：目的研究安络化纤丸对大鼠酒精性脂肪肝(AFLD)形成的预防作用。方法首先经灌胃给予大鼠安络化纤丸预防性治疗4周,后用连续灌服酒精加喂以特制饲料的方法制备大鼠AFLD模型,造模成功后观察一般情况及测定血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(AKP)、甘油三酯(TG)水平,测定肝组织匀浆TG、丙二醛(MDA)及超氧化物歧化酶(SOD)水平,并对大鼠肝脏组织作病理学检查。结果安络化纤丸可明显降低AFLD大鼠血清ALT、AST、AKP、TG水平,降低肝组织TG含量,升高肝组织SOD活性,并降低肝组织MDA水平。肝组织病理学结果表明,安络化纤丸可显著改善AFLD大鼠肝组织的病理损害。结论安络化纤丸有预防大鼠AFLD形成的作用。Purpose To study the preventive effects of Anluohuaxianwan on alcohol-induced fatty liv- er in rats. Methods The rats were received different doses of Anluohuaxianwan for 4 weeks,rat fatty liver model was induced by continuous intragastric administration of alcohol for 6 weeks, and then the animals＇ General conditions, serum Alanine aminotransferase （ALT） and Aspartate aminotransferase （AST） activi- ty. Alkaline phosphatase（AKP） and Triglyceride（TG） levels were observed, hepatic TG, MDA and Su- peroxide dismutase（SOD） levels in liver homogenate and pathological changes in liver were also tested. Results Anluohuaxian can decrease the alcoholic fatty liver serum ALT, AST and AKP levels, decrease the hepatic TG content, increased hepatic SOD activity, and decrease the liver tissue MDA level. Patholog- ical observation results show that Anluohuaxianwan can significantly improve the alcoholic fatty liver path- ological liver tissue damage. Conclusion Anluohuaxianwan has significant preventive effect on alcoholic fatty liver in rats.

关 键 词：安络化纤丸 酒精性脂肪肝 预防 大鼠 

分 类 号：R285.5[医药卫生—中药学]