广西壮族成年人群慢性肾脏病流行情况及危险因素调查研究  

Investigation on Prevalence of Chronic Kidney Disease in Guangxi Zhuang Nationality and Its Risk Factors

作　　者：唐盛[1] 龚智峰[1] 彭小梅[1] 吴潮清[1] 张文欣[1] 刘芸芳[1] 曾春[1] 黄玲[1] 

机构地区：[1]广西壮族自治区人民医院肾内科,广西南宁市530021

出　　处：《中国全科医学》2012年第27期3157-3159,共3页Chinese General Practice

基　　金：广西青年科学基金项目资助(桂科青0832065)

摘　　要：目的了解广西壮族成年人群慢性肾脏病(CKD)流行情况及危险因素,为做好CKD防治工作提供依据。方法 2009年1—12月采用分层多级随机抽样方法,对广西18～75岁壮族居民进行CKD抽样调查。被调查者均接受问卷调查;留取清洁中段随机尿,化学和沉渣分析,计算尿清蛋白/肌酐比值(ACR);检测血肌酐(SCr)、血尿酸(UA)、空腹血糖、口服葡萄糖2 h后血糖、血脂〔总胆固醇(TC)、三酰甘油(TG)〕;行肾脏B超。采用国人校正的简化MDRD公式计算估计肾小球滤过率(eGFR)。同时调查CKD的相关危险因素。结果 (1)本研究资料完整进入统计分析1 296人,其中男629人,女667人;平均年龄(43.4±17.3)岁。其中高血压患病率15.35%(199/1 296),高尿酸血症患病率13.97%(181/1 296),超重或肥胖患病率9.80%(127/1 296),高脂血症患病率6.71%(87/1 296),糖尿病患病率5.48%(71/1 296)。(2)CKD患病136例,患病率为10.49%。男性和女性居民显性清蛋白尿、微量清蛋白尿、单纯血尿、肾功能下降、肾脏形态学异常发生率和CKD患病率比较,差异均无统计学意义(P>0.05)。(3)二项分类Logistic回归分析结果显示,高血压、高尿酸血症、年龄和糖尿病是清蛋白尿的危险因素(P<0.05)。高尿酸血症、高血压、年龄、肾结石是肾功能下降的危险因素(P<0.05)。结论广西壮族成年人群CKD患病率高,CKD相关危险因素包括年龄、高尿酸血症、高血压和糖尿病。我们应努力进行CKD防治工作,做好CKD的宣传教育,积极干预CKD的危险因素,减少CKD的发生、发展。Objective To investigate the prevalence and risk factors of chronic kidney disease （CKD） among Zhuang nationality in Guangxi in order to provide information for the prevention and treatment of CKD. Methods Stratified multistage random sampling method was used to survey CKD among Zhuang nationality from 18 to 75 years old in 2009. All the respondents were surveyed by questionnaires and mid - stream specimen of clean urine was kept and chemical and urine sediment analysis was made on the urine. Urinary albumin/creatinine ratio （ACR） was calculated. SCr, UA, fasting blood glucose, 2 - hour postpran- dial blood glucose and blood lipid （TC, TG） were detected. Then kidney B ultrasound was performed. Corrected and simplified MDRD formula was used to calculate eG~＂Y, and meanwhile, risk factors of CKD were investigated. Results （ 1 ） 1 296 people were involved into the analysis, among which 629 were males and 667 were females; the average age was （43.4 ＋ 17.3 ） years. The incidence of hypertension was 15.35% （ 199/1 296）, the incidence of hyperurieemia was 13.97% （ 181/1 296）, the incidence of overweight or obesity was 9. 80% （ 127/1 296） , the incidence of hyperlipemia was 6.71% （87/1 296） and the incidence of diabetes was 5.48% （71/1 296） . （2） 136 people had CKD with an incidence of 10. 49%. The dominant albumi- nuria, micro -albuminuria, simple hematuria, renal function decline, renal abnormal morphology and CKD incidence between males and females showed no statistically significant differences （ P 〉 0. 05 ） . （ 3 ） Dichotomous classification Logistic regression analysis showed that hypertension, hyperuricemia, age and diabetes were independent risk factors for albuminuria （P 〈 0. 05 ）. Hyperuricemia, hypertension, age and kidney stone were risk factors for renal function decline （ P 〈 O. 05 ） . Conclusion The prevalence of CKD among Zhuang nationality adults in Guangxi is high, and the risk factors for CKD are age, hyperuricemia, hypertension and

关 键 词：慢性肾脏病 患病率 危险因素 壮族 

分 类 号：R692[医药卫生—泌尿科学]