斑马鱼多能性因子的研究进展  

Progress on pluripotency factors in zebrafish

作　　者：胡雨[1] 姚纪花[1] 

机构地区：[1]复旦大学生命科学学院,遗传工程国家重点实验室,上海200433

出　　处：《遗传》2012年第9期1097-1107,共11页Hereditas（Beijing)

基　　金：国家重点基础研究发展计划(973计划)项目(编号:2011CB943804)资助

摘　　要：哺乳动物多能性因子,主要包括Pou5f1/Oct4、Sox2、Klf4、Nanog等转录因子,不仅能够维持胚胎干细胞的未分化状态,同时也参与使分化细胞重编程回多能性状态的过程。目前对脊椎动物多能性因子在体(in vivo)功能研究报道极少。斑马鱼是研究脊椎动物早期发育分化的理想模型,它能够为多能性相关因子的功能研究提供在体环境,因而可以更准确地了解多能性因子的作用信息。近年来,已在斑马鱼中发现了多种哺乳动物多能性因子的同源基因,如oct4、nanog等。文章主要介绍了斑马鱼中多能性因子的相关研究进展,并与其它动物中的研究作一比较。The mammalian pluripotency factors, including transcription factors such as Pou5f1/Oct4, Sox2, Klf4 and Nanog, play critical roles in maintaining pluripotency of embryonic stem cells and inducing reprogramming of differentiated cells. However, the functions of vertebrate pluripotency factors in vivo have not been elucidated. Zebrafish（Danio rerio H.） is an excellent model for studying vertebrates＇ early embryo development. It allows functional studies of pluripotency factors to be conducted in an in vivo environment and therefore provides more accurate information on their roles. Nowadays, several homologs of mammalian pluripotency factors including oct4, nanog etc. have been identified in zebrafish. This review aimed at introducing the progress of the functional study on zebrafish pluripotency factors and comparing to those of other vertebrates.

关 键 词：斑马鱼 多能性因子 类胚胎干细胞 

分 类 号：Q953[生物学—动物学]