2型糖尿病合并高血压患者血清D-二聚体的表达  

Level of plasma D-dimer in the patients of type 2 diabetes meUitus with hypertension

作　　者：崔璐[1] 李睿[2] 高秀兰[1] 陈有霞[1] 陈贵言[1] 陈超[1] 王新军[1] 夏书泽[1] 魏锋[1] 

机构地区：[1]山东省滨州市人民医院内分泌科,256610 [2]山东省滨州市人民医院肾内科,256610

出　　处：《中国综合临床》2012年第10期1022-1024,共3页Clinical Medicine of China

摘　　要：目的研究2型糖尿病合并高血压患者与单纯2型糖尿病患者血浆D-二聚体浓度的不同。方法将85例研究对象分为3组：正常对照组：20例；无高血压的2型糖尿病组：21例；2型糖尿病合并高血压组：44例。测定其血浆D-二聚体浓度并比较组间差异，检测结果数据以均数±标准差表示，组间比较采用方差分析（使用SPSS13．0软件）。结果正常对照组血浆D．二聚体浓度为（102．15±32．48）μg／L，无高血压的2型糖尿病组为（148．62±80．99）μg／L，2型糖尿病合并高血压组为（206．28±92．99）μg／L，无高血压的2型糖尿病组与正常对照组比较，D-二聚体浓度明显升高，差异有统计学意义（P〈0．05）；2型糖尿病合并高血压组与正常对照组比较，D-二聚体浓度也明显升高，差异有统计学意义（P〈0．01）；无高血压的2型糖尿病组与合并高血压组比较差异有统计学意义（P〈0．05）。结论血浆D-二聚体浓度在2型糖尿病及合并高血压患者中明显升高，这可能与凝血和纤溶系统失衡有关，在2型糖尿病及合并高血压患者中监测血浆D-二聚体浓度可能对于预防血栓性疾病有重要的临床意义。Objective To evaluate the plasma D-dimer level in the patients of type 2 diabetes mellitus with hypertension and investigate their correlation. Methods Eighty-five subjects were divided into three groups according to clinical manifestation ： control group ：20 subjects ; type 2 diabetes mellitus group ： 21 subjects ; type 2 diabetes mellitus combined with hypertension group ：44 subjects. The level of plasma D-dimer was measured and the difference was compared between groups. The results were showed as mean ＋ sd, and the difference was compared using ANOVA Test （ SPSS13.0 ）. Results The plasma D-dimer concentrations in normal control group was （ 102. 15 ± 32.48 ） μg/L, in single type 2 diabetes mellitus was （ 148. 62 ±80. 99 ） μg/L, while plasma concentrations in type 2 diabetes mellitus combined with hypertension was （ 206. 28 ± 92. 99 ） μg/L. plasma D-dimer concentration was higher in single type 2 diabetes mellitus than that in normal control cases（ P 〈 O. 05 ） ; And plasma D-dimer concentration was also found increased in type 2 diabetes mellitus combined with hypertension when compared with control group （P 〈 0. 01 ） ;And there was also significant difference on plasma D-dimer concentration between single type 2 diabetes mellitus and type 2 diabetes mellitus combined with hypertension cases （P 〈 0. 05 ）. Conclusion The plasma levels of D-dimer was increased obviously in single type 2 diabetes mellitus and type 2 diabetes mellitus combined with hypertension, it may be related to the imbalance of coagulation and fibrinolytic system. Monitoring of plasma D-dimer concentration in type 2 diabetes and patients with hypertension may have important clinical implications for the prevention of thrombotic diseases.

关 键 词：2型糖尿病 高血压 D-二聚体 

分 类 号：R587.1[医药卫生—内分泌] R544.1[医药卫生—内科学]