血清游离脂肪酸水平与冠状动脉病变的相关性  

Association of serum free fatty acids level with coronary artery disease

作　　者：郝亚平[1] 马晓静[1] 周密[1] 高美芳[2] 陆志刚[2] 杭靖宇[2] 包玉倩[1] 贾伟平[1] 

机构地区：[1]上海交通大学附属第六人民医院内分泌科-上海市糖尿病研究所-上海市糖尿病重点实验室-上海市糖尿病临床医学中心,上海200233 [2]上海交通大学附属第六人民医院心内科,上海200233

出　　处：《复旦学报（医学版）》2012年第5期465-469,共5页Fudan University Journal of Medical Sciences

基　　金：国家科技支撑计划(2009BAI80B01);国家自然科学基金项目(81170788);上海市糖尿病重点实验室基金项目(08DZ2230200)~~

摘　　要：目的探讨血清游离脂肪酸水平与冠状动脉病变的关系。方法选择169例(男性105例,女性64例)接受冠脉造影检查的心内科住院患者,年龄38～86岁,应用冠脉狭窄指数(coronary stenosis index,CSI)评价冠状动脉病变的严重程度。结果 (1)169例研究对象中,115例(男性80例)经冠脉造影证实为冠心病(coronary artery disease,CAD)。男、女性的空腹及餐后2h游离脂肪酸的差异无统计学意义(P>0.05)。(2)与非CAD患者(non-CAD)相比,CAD组空腹游离脂肪酸及CSI评分明显升高(P<0.05),而HDL-c水平降低(P<0.05)。(3)单支病变组及多支病变组空腹游离脂肪酸水平均高于无病变组(P<0.05),但餐后2h游离脂肪酸水平无明显差异(P>0.05)。(4)Logistic回归分析显示,校正其他传统因素后,空腹游离脂肪酸是CAD的独立影响因素。结论血清空腹游离脂肪酸水平与冠状动脉病变相关。Objective To analyze the association of serum free fatty acids （FFA） level with coronary artery disease （CAD）. Methods A total of 169 hospitalized patients （male 105,female 64） who underwent coronary angiography were collected. Severity of CAD was assessed by the coronary stenosis index （CSI）. Results （1） Coronary angiography revealed that 115 （men 80） had CAD. The levels of fasting FFA and 2 h postprandial FFA （2hFFA） showed no difference between men and women （P〉0.05）. （2） The levels of fasting FFA and CSI in CAD patients were higher than non-CAD patients （P〈 0.05 - 0.01） ,however, the level of HDL-c was lower in CAD patients （P〈0.05）. （3） The fasting FFA level was higher in subjects with 1-vessel and multi-vessel lesions than non-CAD patients （P〈0.05）. But there were no differences in the level of 2hFFA （P〉0.05）. （4） Logistic regression demonstrated that fasting FFA was independently correlated with CAD after adjustments of other traditional factors. Conclusions Serum fasting FFA level was associated with coronary artery lesion.

关 键 词：游离脂肪酸 冠心病(CAD) 冠脉造影 

分 类 号：R541.4[医药卫生—心血管疾病]