沐舒坦预防老年患者腹腔镜低位直肠癌术后肺部并发症的研究  

Mucosolvan for prevention of postoperative pulmonary complications after laparoscopic surgery in elder patients with low rectal cancer:a clinical investigation

作　　者：叶俊文[1] 黄美近[1] 蔡永华[1] 王辉[1] 周俊怿[1] 

机构地区：[1]中山大学附属第六医院结直肠外科,广东广州510655

出　　处：《广州医学院学报》2012年第3期26-29,共4页Academic Journal of Guangzhou Medical College

摘　　要：目的:探讨静脉应用3种不同剂量沐舒坦在预防老年患者腹腔镜低位直肠癌术后肺部并发症方面的临床价值。方法:将2010年8月至2011年7月在中山大学附属第六医院行腹腔镜低位直肠癌手术的60例老年患者随机分为A、B、C 3组,A组(20例)常规剂量沐舒坦(30 mg/次,每天3次,连续5 d);B组(20例)中等剂量沐舒坦(90 mg/次,每天3次,连续5 d);C组(20例)较大剂量沐舒坦(300 mg/次,每天2次,连续5 d)。比较3组患者术后排痰情况、肺部并发症、术后平均使用抗生素天数及术后平均住院天数等项目。结果:在咳痰容易程度及痰的性状临床控制方面,B、C组与A组的差异均有统计学意义(P<0.05),B组与C组间差异无统计学意义(P>0.05)。肺部并发症A组与C组间差异有统计学意义(P<0.05),B组与C组间差异无统计学意义(P>0.05)。结论:静脉应用中等剂量沐舒坦在预防老年患者腹腔镜低位直肠癌手术后肺部并发症方面有较好的临床价值。Objective： To investigate the clinical significance of three different doses of intravenous mucosolvan for prevention of postoperative pulmonary complications after laparoseopic surgery in patients with low rectal cancer. Methods ： A total of 60 patients who underwent laparoscopic surgery for low rectal cancer between August 2010 and July 2011 were enrolled in the study and were randomly assigned in group A （n = 20） to receive regular-dose mucosolvan （ 30 rag, thrice daily for 5 consecutive days ） , group B （ n = 20 ） to be treated with moderate-dose mucosolvan （ 90 rag, thrice daily for 5 consecutive days） and group C （ n = 20 ） to administer high-dose mucosolvan （300 mg, twice daily for 5 consecutive days ）. Expectoration, incidence of postoperative pulmonary complications, the average days of postoperative antibiotic use and the length of hospital stay postoperatively were compared. Results： Both groups A and C differed statistically （ both P 〈 0.05 ） in the difficulty in expectoration and sputum physical characters as compared with group B. However, the difference between group B and group C did not reach statistical significance （ P 〉 0.05 ）. There was statistical difference inpostoperative pulmonary complications between group A and group C, but not between group B and group C （ P 〉 0. 05 ）. Conclusion： The moderate-dose intravenous mucosolvan is associated with preferable clinical significance for the prevention of postoperative pulmonary complications after laparoscopic surgery in elderly patients with low rectal cancer.

关 键 词：沐舒坦 老年患者 腹腔镜 低位直肠癌 术后肺部并发症 

分 类 号：R473[医药卫生—护理学]