猪复合皮移植的实验研究  

Experimental study about the grafting of composite skin on swine

作　　者：崔正军[1] 陈璧[2] 夏磊[3] 姜笃银[2] 汤朝武[2] 施新猷[4] 

机构地区：[1]解放军第153中心医院整形烧伤科,郑州450065 [2]第四军医大学西京医院烧伤科,西安7100323 [3]河南医科大学第一附属医院显微外科,郑州4500524 [4]第四军医大学动物实验研究中心,西安710032

出　　处：《河南医科大学学报》2000年第4期322-324,共3页Journal of Henan Medical University

基　　金：全军指令性课题!3 90 70 82 2

摘　　要：目的 :为使复合皮移植的动物实验结果进一步接近临床 ,用小香猪作动物模型 ,探讨复合皮移植的术后效果和成活机制。方法 :实验分 3组 ,A组为移植异体普通乳猪真皮 +成年小香猪自体表皮皮片 ;B组为移植异体成年小香猪真皮 +成年小香猪自体表皮皮片 ;C组为移植成年小香猪自体表皮皮片。术后观察 3组皮片的存活质量及组织学变化。结果 :3组皮片早期成活情况均较好 ,A组和B组晚期收缩率及瘢痕程度均比C组低。A组和B组的组织学结构较完整 ,异体普通乳猪真皮的成活情况优于异体成年小香猪真皮。结论 :异体真皮的存在能改进复合皮移植的质量 。Aim:Swine were used as animal models for composite skin to make their experimental results close to clinic, and to explore their survival mechanism and results after the operations. Methods:Three groups were designed:in group A, allogenic dermis of new borne swine and autologous epidermis grafts were transplanted; but in group B, the allogenic dermis of adult swine and autologous epidermis graft; in group C, only the autologous epidermis graft. After the operations, the grafts were observed and tissue was obtained for histological study. Results: The survival status in 3 groups were satisfied in early time. The contractive rate and scar forming in group A and group B were lower than those in group C. There was much integral histological structure in group A and group B than that in group C, and the survival status in allogenic dermis of new borne swine was better than that in allogenic dermis of adult swine. Conclusion:Allogenic dermis can improve the composite skin's quality, furthermore, the composite skin having allogenic dermis of sucking swine has the best result.

关 键 词：动物模型 猪复合皮 皮肤移植 免疫排斥 

分 类 号：R622.1[医药卫生—整形外科]