乌司他丁对脓毒症患者C-反应蛋白及血管内皮生长因子表达的影响  

作　　者：封萍[1] 陈艳明[2] 廖谷清[1] 

机构地区：[1]南华大学附属南华医院ICU,412002 [2]南华大学附属第二医院,421001

出　　处：《当代医学》2012年第29期3-4,共2页Contemporary Medicine

摘　　要：目的研究乌司他丁对脓毒症患者C-反应蛋白(CRP)及血管内皮生长因子(VEGF)表达的影响。方法 40例脓毒症患者随机分为常规治疗组和乌司他丁组各20例,两组均予以抗休克和病因治疗。在此基础上,乌司他丁组加用乌司他丁(20万U,每8小时1次,治疗7d),观察治疗前和治疗后的外周血CRP、VEGF与急性生理与慢性健康评分(APACHEII)的动态变化。结果治疗前两组外周血CRP及VEGF差异无统计学意义。常规治疗组第7天外周血CRP及VEGF分别为(59±28)ng/L,(97±28)ng/L;乌司他丁组治疗第7天外周血CRP及VEGF分别为(31±16)ng/L,(41±10)ng/L。乌司他丁组治疗后第7天的外周血CRP及VEGF较治疗前明显下降(P<0.05),且较常规治疗组下降明显(P<0.05)。乌司他丁组治疗后第10天的APACHEII评分([11±6)分]明显低于常规治疗组([15±7)分](P<0.05)。结论乌司他丁可以降低脓毒症患者外周血CRP、VEGF与APACHEII评分的水平,改善预后,其作用机制可能是通过降低血中的VEGF表达水平。Objective To explore the effects of ulinastatin on level of serum C-reactive protein（CRP） and vascular endothelial growth factor（VEGF） in patients with sepsis. Methods Forty patients with sepsis were randomly divided into 2 groups-the conventional therapy group and the ulinastatin group. The conventional therapy group accepted the general treatment. The ulinastatin group accepted ulinastatin injection in addition. The levels of serum CRP and VEGF were measured, and APACHE Ⅱ scores were included as well. Results Serum CRP and VEGF after the treatment with ulinastatin were significantly decreased compared with that before treatment （P〈0.05）. APACHE Ⅱ scores in the two groups at the 10th day after admission have significant difference （P〈0.05）. Conclusion Ulinastatin can decrease the expression levels of serum CRP and VEGF, and APACHE Ⅱ scores were included as well. The mechanism is involved in the down-regnlation of VEGF.

关 键 词：乌司他丁 C-反应蛋白 血管内皮生长因子 

分 类 号：R459.7[医药卫生—急诊医学]