复方甘草酸苷联合多烯磷脂酰胆碱治疗伴肝损害的寻常型银屑病  

Compound glycyrrhizin combined with polyene phosphatidylcholine in the treatment of psoriasis vulga-ris with liver damage

作　　者：杨凤元[1] 陈德华[1] 黄熙[1] 

机构地区：[1]桂林医学院附属医院皮肤科,广西桂林541001

出　　处：《华夏医学》2012年第4期495-498,共4页Acta Medicinae Sinica

摘　　要：目的:探讨复方甘草酸苷联合多烯磷脂酰胆碱治疗伴肝损害的寻常型银屑病的疗效。方法:62例患者随机分为2组。对照组30例,予复方甘草酸苷注射液静滴,同时外用复方氟米松软膏及尿素乳膏。治疗组32例,在对照组的基础上加用多烯磷脂酰胆碱注射液静滴。2组治疗后观察疗效。结果:治疗组临床有效率(78.13%)高于对照组(53.33%);治疗组治疗后PASI评分(5.92±3.63)低于对照组(8.10±4.22);2周后治疗组血清ALT(69.03±30.08),AST(67.47±22.34)均低于对照组ALT(84.93±31.93),AST(83.2±37.89);差异均有统计学意义(P<0.05)。结论:复方甘草酸苷联合多烯磷脂酰胆碱治疗伴肝损害的寻常型银屑病的临床疗效优于单用复方甘草酸苷。Objective： To study the efficacy of compound glycyrrhizin combined with polyene phosphatidyl choline in treatment of psoriasis vulgaris with liver damage.Methods： 62 patients were randomly divided into the control group（n=30） and treatment group（n=32）.The control group was treated with the compound glycyrrhizin combined with compound flumetasone ointment and urea cream.Based on the treatment of control group,the treatment group were treated with addition of polyene phosphatidyl choline.The efficacy of treatment were analyzed.Results： The clinical efficiency of treatment group was 78.13%,higher than that of control group 53.33%;After treatment,PASI score of the treatment group was 5.92± 3.63,lower than that of control group 8.10 ±4.22;2 weeks after treatment,that serum ALT and AST were 69.03 ±30.08 and 67.47 ±22.34 in treatment group was lower than that in control group ALT 84.93 ±31.93 and AST 83.2 ±37.89,the differences were statistically significant（P〈0.05）.Conclusion： Clinical curative effect of compound glycyrrhizin combined with polyene phosphatidylcholine is better than that of compound glycyrrhizin alone in the treatment of psoriasis vulgaris with liver injury.

关 键 词：复方甘草酸苷 多烯磷脂酰胆碱 肝损害 寻常型银屑病 复方氟米松 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]