氯沙坦治疗老年高血压伴肾损害的疗效观察  

OBSERVATION ON EFFECTIVENESS OF LOSARTAN IN SENILE HYPERTENSION WITH RENAL IMPAIRMENT

作　　者：陆文俊[1] 严震文[1] 朱永奋[1] 朱毅[1] 王群献[1] 

机构地区：[1]上海市华东医院肾内科,200040

出　　处：《老年医学与保健》2000年第2期90-91,98,共3页Geriatrics & Health Care

摘　　要：目的　探讨氯沙坦在老年高血压伴肾损害病人中，对蛋白尿的影响。方法 ３０例老年高血压病患者，平均年龄７７．３６ ± ５．６岁，口服氯沙坦，疗程１２周，治疗前后观察血压，２４小时尿蛋白，肾功能变化。结果　氯沙坦能有效地降低尿蛋白排泄［２４小时尿蛋白（ｇ／２４ｈ）：０．９９±０．３３降至０．７８±０．３１，Ｐ＜０．０５），与其他降压药联合服用有更好的降压作用。结论　对高血压合并肾损害患者，每日１次氯沙坦５０ｍｇ或１００ｍｇ能有效降低尿蛋白排泄，其机理可能是肾内血流量的改变所致。Objective To observe the effect of insartan on proteinuria in senile hypertension with renal impairment. Methods 30 cases with hypertension, the average age 77. 36 ± 5.6, were taken Losartan for 12 weeks. Before and after treatment, parameters such as blood pressur, urine protein/24h, and renal function were measured. Results Losartan can reduce urinary protein excretion effectively [urinary protein excretion/24h(g/24h): 0. 99 ± 0. 33 vs 0 .78 ± 0. 31, P < 0 .05]. It is better to lower the blood pressure with other antihypertensive drugs. Conclusions It is shown that Losartan with a dose of 50mg or 100mg daily can reduce urinary protein excretion in hypertensive patients with renal impairment. It is probable that the positive effect of insartan on proteinuria is attributable to the change of intrarenal hemodynamics.

关 键 词：氯沙坦 老年人 高血压 蛋白尿 肾损害 药物疗法 

分 类 号：R544.1[医药卫生—心血管疾病]