EPO对中重度新生儿低氧缺血性脑病的保护作用  

PROTECTIVE EFFECT OF ERYTHROPOIETIN ON NEONATES WITH HYPOXIC-ISCHEMIC ENCEPHALOPATHY

作　　者：程琪[1,2] 姜红[1] 

机构地区：[1]青岛大学医学院附属医院新生儿科,山东青岛266003 [2]聊城市人民医院新生儿科

出　　处：《青岛大学医学院学报》2012年第5期413-415,共3页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的探讨促红细胞生成素(EPO)对中重度新生儿低氧缺血性脑病(HIE)的保护作用。方法选取生后72h内入住新生儿重症监护室(NICU)的中重度HIE新生儿48例,随机分为治疗组(A组,其中中度HIE(A1组)16例,中度HIE(A2组)8例)和对照组(B组,其中中度HIE(B1组)16例,重度HIE(B2组)8例)。治疗组除对照组常规治疗外,加用EPO治疗。ELISA法测定各组神经元特异性烯醇化酶(NSE)、S-100蛋白(S-100)的水平。结果各组治疗7、14d后NSE水平均较治疗前明显降低,差异有显著性(F=3.36～10.39,q=3.34～6.78,P<0.05)。A1组治疗7d后NSE水平与B1组比较,差异有显著性(F=8.26、4.39,q=5.23,P<0.01),而治疗14d后,两组间比较差异无显著性。治疗7、14dA2组NSE水平与B2组比较,差异均有显著性(q=5.56、4.32,P<0.01)。各组治疗7、14d后S-100蛋白水平均较治疗前明显降低,差异有显著性(F=4.51、5.68,q=3.93～4.00,P<0.05)。A1组治疗7、14d后S-100蛋白水平与B1组比较差异均有显著性(F=5.12、7.06,q=3.99、6.97,P<0.05)。A2组治疗7d后S-100蛋白水平与B2组比较明显下降,差异有显著性(q=3.93,P<0.05)。结论 EPO可明显降低中重度HIE病儿体内的NSE、S-100蛋白水平,改善其预后。Objective To explore the protective effect of erythropoietin（EPO） on neonates with moderate or severe hypoxic-ischemic encephalopathy（HIE）.Methods Forty-eight neonates of 72 hours after birth with HIE were selected from neonatal intensive care unit（NICU）,who were randomized to treatment group（group A）,in which,group A1 16 cases,and group A2,eight cases;and control group（group B）,in which,group B1 16 cases,and group B2,eight cases.The neonates in group A were given EPO besides the same routine therapy as in the group B.ELISA was applied to detect the levels of NSE and S-100 protein.Results After seven and 14 days of therapy,the levels of NSE in each group of group A were much lower than that before treatment（F=3.36-10.39;q=3.34-6.78;P〈0.05）.After seven days of treatment,the difference of NSE level between group A1 and group B1 was significant（F=8.26,4.39;q=5.23;P〈0.01）;while after 14 days of treatment,the difference between the two groups was not significant.After seven and 14 days of treatment,the difference of NSE levels between group A2 and group B2 was significant（q=5.56,4.32;P〈0.01）.After seven and 14 days of treatment,the levels of S-100 in each group declined greatly as compared with that before treatment（F=4.51,5.68;q=3.93-4.00;P〈0.05）.In group A1,the levels of S-100 were significantly different as compared with group B2 after seven and 14 days of treatment（F=5.12,7.06;q=3.99,6.97;P〈0.05）;in group A2,the levels of S-100 decreased much greater than that in group B2（q=3.93,P〈0.05）.Conclusion EPO can obviously reduce the levels of NSE and S-100 in sick kids with HIE,and improve their prognosis.

关 键 词：红细胞生成素 低氧缺血 脑 婴儿 新生 磷酸丙酮酸水合酶 S100蛋白质类 

分 类 号：R722.1[医药卫生—儿科]