脂肪乳注射液治疗中呼吸困难加重原因多因素分析  

MULTIPLE REGRESSION ANALYSIS OF THE CAUSE OF DYSPNEA IN INTRAVENOUS INFUSION OF FAT EMULSION INJECTION

作　　者：徐峰[1] 徐德祥[1] 

机构地区：[1]青岛大学医学院第二附属医院呼吸科,山东青岛266042

出　　处：《青岛大学医学院学报》2012年第5期426-428,共3页Acta Academiae Medicinae Qingdao Universitatis

基　　金：青岛市科技局立项课题(07-2-1-12-nsh)

摘　　要：目的探讨脂肪乳输液治疗中呼吸困难加重的原因,为临床预防相关不良反应提供依据。方法在我院呼吸科与危重症科连续观察200例静脉使用脂肪乳的呼吸困难病人,记录病人的一般状况、基础疾病、脂肪乳的性状、输注方法以及输注脂肪乳前后呼吸困难程度等指标。使用Logistic回归方法进行多因素分析。结果输注速度过快、单一输注脂肪乳和经外周通路输液是加重呼吸困难的独立危险因素。结论呼吸困难病人输注脂肪乳时采取混合输注、减慢输注速度和中心静脉途径可以减少呼吸困难加重的不良反应。Objective To investigate the cause of dyspnea during intravenous infusion of fat emulsion injection,and provide evidence for its prevention accordingly.Methods A successive observation was conducted in 200 patients-in department of respirology and ICU-with dyspnea caused by intravenous intralipid therapy.Their general condition,underlying diseases,the cha-racteristics of the intralipid,the method of infusion,and the degree of dyspnea,before and after the infusion,was recorded.Logistic regression analysis was done for the findings.Results The independent risk factor of aggravating dyspnea was fast infusion,single infusion of intralipid and through peripheral vein.Conclusion For patients with dyspnea,combined infusion of intralipid should be adopted,stepping down the rate of infusion and through central vein can decrease the adverse effects of aggravation of dyspnea.

关 键 词：脂肪乳剂 静脉注射用 呼吸困难 回归分析 

分 类 号：R459.3[医药卫生—治疗学]