复方甘草酸苷并阿维A治疗泛发性脓疱型银屑病效果  

CLINICAL EFFICACY OF COMPOUND GLYCYRRHIZIN COMBINED WITH ACITRETIN FOR GENERALIZED PUSTULAR PSORIASIS

作　　者：于文强[1] 

机构地区：[1]青岛市市立医院皮肤科,山东青岛266011

出　　处：《青岛大学医学院学报》2012年第5期437-438,440,共3页Acta Academiae Medicinae Qingdao Universitatis

摘　　要：目的观察复方甘草酸苷联合阿维A治疗泛发性脓疱型银屑病的临床效果。方法 90例病人随机分为治疗组和对照组。治疗组采用阿维A胶囊0.75mg/(kg.d)治疗,最大剂量不超过75mg/d,逐渐规律减量至10～20mg/d维持,同时联合应用复方甘草酸苷粉60～80mg入50g/L的葡萄糖溶液或生理盐水250mL中静脉滴注。对照组单纯口服阿维A治疗,用法同治疗组。两组均治疗8周后评定疗效。结果治疗组中2例出现双下肢轻度水肿,3例出现低钾血症。对照组中3例出现肝脏转氨酶轻度升高,2例服用阿维A无效。两组疗效比较差异有显著性(Uc=2.32,P<0.05)。结论复方甘草酸苷联合阿维A治疗泛发性脓疱型银屑病临床疗效确切,且可减少阿维A的副作用,值得临床推广应用。Objective To observe the clinical efficacy of compound Glycyrrhizin combined with Acitretin for generalized pustular psoriasis（GPP）.Methods Ninety GPP patients were randomized to treatemnt group and control group.For patients in the treatment group were treated with Acitretin capsule（0.75 mg·kg^-1·d^-1）,the maximal dose was not over 75 mg/d,the dose was gradually decreased to 10-20 mg/d,and maintained.At the same time,compound Glycyrrhizin powder dissolved in50 g/L glucose or 250 mL of normal saline was offered intravenously.For those in the control group,oral Acitretin only was gi-ven.The efficacy was assessed after eight weeks of therapy.Results In the treatment group,two patients developed mild edema of both lower extremities,three appeared kaliopenia;those in the control group,three appeared higher aminopherase,and two did not response to Acitretin.The effect of therapy is different between the two groups（Uc=2.32,P〈0.05）.ConclusionCompound Glycyrrhizin combined with Acitretin is effective for GPP,whiuch can also reduce the side effects of Acitretin.

关 键 词：复方甘草酸苷 阿维A胶囊 银屑病 治疗结果 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]