妊娠期糖尿病胰岛素抵抗与IL-10及CRP的相关性  

CORRELATION BETWEEN INSULIN RESISTANCE IN GESTATIONAL DIABETES MELLITUS WITH INTERLEUKIN-10 AND C-REACTIVE PROTEIN

作　　者：刘爱红[1] 解梅林[1] 孙选[1] 臧琳琳[2] 李旭日[1] 邹珺[1] 

机构地区：[1]青岛海慈医疗集团妇产科,山东青岛266033 [2]青岛海慈医疗集团检验科,山东青岛266033

出　　处：《青岛大学医学院学报》2012年第6期507-508,共2页Acta Academiae Medicinae Qingdao Universitatis

基　　金：青岛市公共领域科技支撑计划立项课题(10-3-3-5-2-nsh)

摘　　要：目的探讨妊娠期糖尿病(GDM)病人血清白细胞介素10(IL-10)和C反应蛋白(CRP)与胰岛素抵抗的关系。方法选择妊娠中期GDM病人40例,采集静脉血检测血清中IL-10、空腹胰岛素(FINS)、空腹血糖(FBS)及CRP的水平。以同期糖耐量正常孕妇50例作为对照组。结果 GDM组FBS、FINS、胰岛素抵抗指数(IRI)及CRP显著高于对照组(t=2.690～13.580,P<0.01);IL-10显著低于对照组(t=20.123,P<0.01)。GDM病人CRP与IRI呈显著正相关(r=0.865,P<0.01),IL-10与IRI呈显著负相关(r=-0.805,P<0.05)。结论炎性递质与GDM发生相关,CRP升高、IL-10降低均加重胰岛素抵抗,促进高糖血症发生。Objective To investigate the relationship between serum IL-10,CRP in gestational diabetes mellitus（GDM） and insulin resistance index（IRI）.Methods Forty GDM patients were enrolled,serum IL-10,fasting blood sugar（FBS）,fas-ting insulin（FINS） and CRP were measured,and 50 normal-sugar-tolerance pregnant women of the corresponding time period were served as controls.Results In GDM group,the levels of FBS,FINS,IRI and CRP were higher than that in the control group（t=2.690-13.580,P〈0.01）,and IL-10 was lower（t=20.123,P〈0.01）.In GDM patients,CRP was positively correlated with IRI（r=0.865,P〈0.01）,and IL-10 was negatively correlated with IRI（r=-0.805,P〈0.05）.Conclusion Inflammatory transmitters are associated with the development of GDM,both elevation of CRP and reduction of IL-10 aggravate the resistance of insulin and promote the occurrence of hyperglycemia.

关 键 词：糖尿病 妊娠 胰岛素抵抗 白细胞介素10 C反应蛋白 

分 类 号：R714.25[医药卫生—妇产科学]