飞龙掌血水提物对心肌缺血兔心功能和血液动力学的影响  

Effects of aqueous extract from toddalia asiatica on cardiac function and hemodynamics in myocardial ischemic rabbits

作　　者：叶开和[1] 任先达[1] 熊爱华[1] 杨延秀[1] 

机构地区：[1]暨南大学医学院药理学教研室,广东广州510632

出　　处：《中国病理生理杂志》2000年第7期606-609,共4页Chinese Journal of Pathophysiology

基　　金：广东省中医药管理局科学基金资助! (96 141)

摘　　要：目的 :观察飞龙掌血 (ToddaliaasiaticaLam)水提物 (飞龙一号 ,F0 1)对急性心肌缺血动物模型心脏功能和血液动力学的影响。方法 :新西兰兔作不开胸膜冠脉左前降支高位结扎造成急性心肌缺血 ,观测结扎后及F0 1ip对动物心功、血液动力学的影响。结果 :冠脉左前降支结扎后 ,LVEDP显著升高 (P <0 .0 5 ) ,t -dp/dtmax无明显变化 ,其余各项参数均明显降低 (P <0 .0 5或P <0 .0 1)。F0 1(2 6 8mg/kg)腹腔注射后 ,除有关左室作功和心肌耗氧的参数 (HR、TTI和TTI×HR)继续降低外 ,其余各项参数的变化均显著逆转 ,恢复或接近结扎前的水平 ,用药后 1 5h的作用较 0 5h更明显。结论 :F0 1可显著减少急性缺血心肌的作功和耗氧 ,通过纠正心脏对氧的供需平衡失调 ,改善心脏收缩、舒张功能和泵血功能 ,从而发挥对缺血心肌的保护作用。AIM: To observe the effects of toddalia asiatica aqueous extract (Fei Long No 1, F01) on cardiac function and hemodynamics of acute myocardial ischemia in the animal model. METHODS: High positioned double-ligation of the anterior descending left coronary artery induced acute myocardial ischemia in New Zealand rabbits. F01 268 mg/kg were ip into the acute myocardial ischemic model, Cardiac function and hemodynamic measurements were performed before and after ligation and administration of F01. t -test paired was used for statistical analysis. RESULTS: After ligation all indices was reduced significantly except that LVEDP was markedly increased and t-dp/dt max had little change. After administration of F01 changes of most indices were reversed, and returned to or were close to the baseline. 1.5 h after administration of F01 action was more markedly. But the indices of left ventricle work and consumption of oxygen ( HR, TTI and TTI×HR) were reducing continuously. CONCLUSION: F01 markedly decreases ventricle work and consumption of oxygen of acute ischemic myocardium, so that the contractility, diastolic function of myocardium and cardial output are improved. These are the mechanism of protective effect on myocardial ischemia.

关 键 词：中草药 心肌缺血 血液动力学 飞龙掌血水提物 

分 类 号：R259.422[医药卫生—中西医结合] R285.5[医药卫生—中医内科学]