正常妊娠对灵长目前房相关免疫偏离的影响  

Effects of normal pregnancy on anterior chamber-associated immune deviation in primates

作　　者：李志杰[1] 彭广华[1] 李辰[1] 

机构地区：[1]暨南大学组织移植与免疫实验中心,眼科学实验室广东广州510632

出　　处：《中国病理生理杂志》2000年第7期637-639,共3页Chinese Journal of Pathophysiology

基　　金：国家自然科学基金! (No .39970 2 5 0 );教育部霍英东教育基金会;广东省自然科学基金资助

摘　　要：目的 :最近发现兔正常妊娠期间伴随前房相关免疫偏离 (ACAID)的消失。本研究旨在进一步观察在接近人类的灵长目动物是否发生同样的事件。方法 :随机选取中期妊娠恒河猴。将牛血清白蛋白 (BSA)接种于非妊娠和中期妊娠猴眼前房。后使用加有佐剂的BSA免疫动物。然后再使用BSA刺激皮肤评估诱导的迟发型超敏反应 (DTH)。结果 :前房接种BSA的非妊娠猴均获得抗原特异性迟发型超敏反应的抑制。与此相反 ,将BSA接种于妊娠猴眼则消除对DTH的抑制效应。结论 :灵长目动物在正常妊娠期间ACAID消失 ;AIM:Recently it was found that loss of anterior chamber-associated immune deviation (ACAID) was associated with normal pregnancy in rabbits. The purpose of this study is to further investigate whether the same events occurred in nonhuman primates. METHODS:Mid-pregnant cynomolgus monkeys were randomly selected. Bovine serum albumin (BSA) or balanced salt solution was inoculated in anterior chamber of eyes of nonpregnant and mid-pregnant monkeys that were subsequently immunized with BSA in adjuvant and then skin was challenged for delayed-type hypersensitivity with BSA. RESULTS: Non-pregnant monkeys of intracameral BSA were able to acquire antigen-specific suppression of delayed-type hypersensitivity. By contrast, inoculation of BSA to anterior chamber of pregnant monkeys abolished the DTH-suppression effect. CONCLUSIONS: This is the first demonstration in primates that loss of anterior chamber-associated immune deviation occurred during normal pregnancy. The fluctuations of systemic hormone levels during normal pregnancy might influence local immunoregulation within the eye.

关 键 词：正常妊娠 灵长目动物 眼前房相关免疫偏离 

分 类 号：R714.106[医药卫生—妇产科学] R770.2[医药卫生—临床医学]