主动脉内球囊反搏术治疗急性心肌梗死的疗效和安全性观察  

Clinical efficacy and safety of intra-aortic balloon pump in patients with acute myocardial infarction

作　　者：黄志文[1] 陈小卫[1] 田丽红[1] 吴铿[1] 

机构地区：[1]广东医学院附属医院心内科,广东湛江524001

出　　处：《广东医学院学报》2012年第3期250-253,257,共5页Journal of Guangdong Medical College

基　　金：广东省科技计划项目(No.2009B030801338)

摘　　要：目的观察主动脉内球囊反搏术(IABP)治疗急性心肌梗死(AMI)的疗效和安全性。方法 80例AMI患者随机分为IABP组和对照组,每组40例。两组均给予WHO规定的标准基础治疗方案及PCI治疗,IABP组在PCI前使用IABP治疗。观察治疗前后两组脑利钠肽水平、肌钙蛋白I水平、左心室舒张末期容积(LVEDV)、左心室收缩末期容积(LVESV)和射血分数变化、治疗后30d内主要心血管事件。结果与对照组比较,IABP的使用显著降低心肌梗死后1周脑利钠肽及肌钙蛋白I水平(P<0.01),缩小LVEDV和LVESV(P<0.01或0.05),提高LVEF(P<0.01),降低30d内主要心血管事件的发生率(P<0.01)。结论 IABP的使用能改善梗死后心肌缺血程度、心室压力、容量负荷和心室重构,从而改善AMI患者的预后。Objective To observe the clinical efficacy and safety of intra-aortic balloon pump （IABP） in patients with acute myocardial infarction （AM-I）. Methods Eighty cases of AMI were divided into control and treatment groups. Both groups accepted the WHO＇s standard foundation treatment and PCI, while treatment group were treated with additional IABP before PCI. Level of brain natriurvtic pcptide （BNP） and troponin I, left ventricular end-diastolic volume （LVEDV）, left ventricular end- systolic volume （LVESV）, left vantricular ejection fraction （LVEF）, and major cardiovascular events during 30 days were evaluated in all patients before and after treatment. Results Compared with control group, level of BNP and troponin I during one week, incidence of major cardiovascular events during 30 days, LVEDV, and LVESV decreased （P〈0.01 or 0.05）, while LVEF increased （P〈0.01） in treatment group. Conclusion IABP can improve myocardial ischcmia, ventricular pressure, volume load, ventricular remodeling and prognosis in AMI patients.

关 键 词：主动脉内球囊反搏术 脑利钠肽 急性心肌梗死 肌钙蛋白I 

分 类 号：R542.22[医药卫生—心血管疾病]