孕妇在不同糖耐量状态下胰岛β细胞分泌功能和胰岛素抵抗与C肽的关系研究  

Study on Relationship of Islet β-cell Function, Insulin Resistance and Fasting C-peptide of Pregnant Women with Different Glucose Tolerances

作　　者：吴正林[1] 何涛君[1] 侯学荣[2] 钟小强[1] 陈晓燕[1] 陆学东[1] 

机构地区：[1]深圳市第四(福田)人民医院检验医学部,广东深圳518033 [2]广东医学院2007级,广东深圳518033

出　　处：《现代检验医学杂志》2012年第4期53-54,57,共3页Journal of Modern Laboratory Medicine

摘　　要：目的探讨妊娠妇女在不同糖耐量状态下胰岛β细胞分泌功能、胰岛素抵抗与C肽含量变化的关系。方法分析77例妊娠糖尿病（GDM）孕妇、和66例糖耐量正常（NGT）孕妇的胰岛素抵抗状况胰岛β细胞分泌功能，采用相关C肽水平值计算胰岛素抵抗指数和胰岛β细胞功能的公式Homa-islet（CP-DM）=0．27×空腹C肽／（空腹血糖-3．5），Homa-IR（CP）=1．5＋空腹血糖×空腹C肽／2800来评价胰岛β细胞分泌功能和胰岛素抵抗状况。结果GDM组的C肽水平值和Homa—IR（CP）结果明显高于NGT组结果，两组差异有统计学意义（P〈0．05）；NGT组的胰岛β细胞功能指数Homa-islet（CP）略低于GDM组，差异无统计学意义（P〉0．05）。结论妊娠糖尿病患者同正常糖耐量孕妇相比C肽水平和胰岛素抵抗指数明显升高，但胰岛β细胞功能指数无统计学差异；C肽水平目前还无法完全评价胰岛β细胞分泌功能和胰岛素抵抗状况。Objective Using C-peptide to investigate the changes of insulin resistance and function of islet β- cell of pregnant women with different glucose tolerances. Methods 77 patients with normal glucose tolerance （NGT） ,and 66 patients with gestational diabetes mellitus（GDM） were observed. Two formulas were used to investigate the changes of insulin resistance（IR） and the function of islet β-celh Homa-islet （CP-DM） = 0. 27 × fasting C-peptide/（fasting blood glucose--3.5）, Homa-IR（CP） = 1.5 ＋ （fasting blood glucose× fasting C-peptide/2800. Results Compared with the NGT group, the GDM group had higher fasting C-peptide level and insulin resistance index （P〈0. 05）, the function index of islet β-cell of the two groups were similar. There was no significantly difference between the two groups （ P〉0. 05）. Conclusion There was significantly difference between the C-peptide and insulin resistance index of the NGT and GDM groups. The function index of islet β-cell of the two groups was similar. C-peptide may not be a entirely index to investigate the changes of insulin resistance and function of islet β-cell.

关 键 词：妊娠糖尿病 胰岛Β细胞功能 胰岛素抵抗 C肽 

分 类 号：R714.256[医药卫生—妇产科学] R392.11[医药卫生—临床医学]