Toll样受体在小儿轮状病毒感染中的研究进展  

Toll-like receptor in children＇s rotavirus infection

作　　者：杨海燕(综述)[1] 陈兰举(审校)[1] 

机构地区：[1]蚌埠医学院第一附属医院儿科,233004

出　　处：《国际儿科学杂志》2012年第5期441-444,共4页International Journal of Pediatrics

摘　　要：Toll样受体是识别病原体病原相关分子模式的受体，是天然免疫和获得性免疫的桥梁，Toll样受体通过识别病原体，激活天然免疫，诱导产生多种细胞因子，影响初始T细胞的分化，目前认为识别轮状病毒和抗轮状病毒天然免疫反应有密切关系的Toll样受体主要有TLR2、3、4、7、8、9。Toll-like receptor is a receptor to identify the pathogen associated molecular, which relates the natural immune with required immune. Toll-like receptor activates natural immune and induces several cyto- kines. As a result, it will influence the differentiation of initiated T-cell by identifying Pathogens. The main Toll- like including TLR2,3,4,7,8,9 are closely related with anti-rotavirus to identify the natural immune affection of rotavirus. This review to explain the pathogenesis of Toll-like in rotavirus infection, as well as the key role which Toll-like plays in preventing rotavirus infection and controlling the inflammation.

关 键 词：TOLL样受体 轮状病毒 信号传导 天然性免疫 获得性免疫 

分 类 号：R725.161[医药卫生—儿科]