美托洛尔对大鼠心肌梗死后心力衰竭的保护作用  

Protective effect of metoprolol on heart failure of rats after myocardial infarction

作　　者：黄飞飞[1] 

机构地区：[1]同济大学附属同济医院心内科,上海200065

出　　处：《国际心血管病杂志》2012年第5期306-308,共3页International Journal of Cardiovascular Disease

摘　　要：目的:研究美托洛尔对大鼠心肌梗死后心力衰竭的保护作用及其可能机制。方法:结扎大鼠左冠状动脉制备心力衰竭大鼠模型,将大鼠随机分为伪手术组、模型组和美托洛尔(10 mg.kg-1.d-1)处理组,并给药6周。6周后进行血流动力学检查,观测心肌细胞凋亡情况以及凋亡相关因子Bcl-2、Bax的表达。结果:美托洛尔能明显改善心功能;减少心肌细胞凋亡;抑制Bcl-2表达,促进Bax表达。结论:美托洛尔对心肌梗死后心力衰竭具有一定的保护作用,其部分机制可能是通过抑制心肌细胞凋亡实现的。Objective： To study the protective effect of metoprolol on heart failure in rats after myocardial infarction. Methods： Heart failure model after myocardial infarction was made by ligating the left anterior descending coronary artery. The rats were randomly divided into sham, model and metoprolol （10rag . kg -1. d -1 ） treated groups. The drug or vehicle was given by gastric perfusion for 6 weeks after operation and then the hemodynamic parameters were detected, TdT-mediated dUTP nick end labe ling was used to examine apoptosis of heart tissues, and western blotting was used to analyze the protein expression of Bcl-2 and Bax. Results： Metoprolol was found to decrease the LVEDP and increase the LVSP and ±LVdp/dt ; compared with model group, metoprolol improved the heart function significantly. Furthermore, metoprolol inhibited myocardial apoptosis which was approved by TUNEL. Additionally, metoprolol inhibited Bax protein expression and promoted Bcl-2 protein expression.Conclusion.. Metoprolol protects the development of heart failure in rats after myocardial infarction probably by inhibiting myocardial apoptosis.

关 键 词：美托洛尔 心肌梗死 心力衰竭 凋亡 

分 类 号：R541.6[医药卫生—心血管疾病]