脊髓中S100b基因的表达模式研究  

S100b Gene Expression Pattern in Spinal Cords

作　　者：黄浩[1] 赵晓枫[1] 邱猛生[1] 

机构地区：[1]杭州师范大学生命与环境科学学院,浙江杭州310036

出　　处：《杭州师范大学学报（自然科学版）》2012年第5期391-396,共6页Journal of Hangzhou Normal University(Natural Science Edition)

基　　金：国家自然科学基金项目(31000488)

摘　　要：S100b是一种钙离子结合蛋白,与阿尔兹海默症、帕金森症、神经痛等多种神经系统疾病有关.实验通过原位杂交和免疫荧光技术对S100b在中枢神经系统的表达模式进行直接分析,发现S100b主要表达在脊髓灰质星形胶质细胞和脊髓白质中正在成熟的少突胶质细胞中,表明其并不能很好的作为星形胶质细胞的分子标记物.SlOOb is a calcium binding protein implicated in many nervous system diseases, such as Alzheimer＇s disease, Parkinson＇s disease and Neuropathic pain, etc. The experiment used situ hybridization and immunofluorescence to analyze SlOOb expression in CNS. The results show that SlOOb is mainly expressed in the astrocytes of gray matter and the maturing oligodendrocytes in white matter of spinal cords, which indicates that SlOOb is not a good molecular marker for astrocytes.

关 键 词：S100B 星形胶质细胞 少突胶质细胞 脊髓 

分 类 号：Q189[生物学—神经生物学]