呋塞米与托拉塞米间隔使用治疗慢性心力衰竭的临床观察  

Clinical observation of interval usage of furosemide and torasemide in treatment of chronic heart failure

作　　者：任诗佳 郑继平[1] 徐恩国 杨建广[1] 

机构地区：[1]浙江省台州市第一人民医院心内科,浙江台州318020

出　　处：《药学实践杂志》2012年第4期291-292,319,共3页Journal of Pharmaceutical Practice

摘　　要：目的探讨呋塞米与托拉塞米间隔使用治疗慢性心力衰竭(CHF)的疗效。方法将符合纳入标准患者随机分成试验组和对照组。试验组先使用呋塞米片7 d,然后改为托拉塞米片7 d;对照组使用呋塞米片14 d。比较两组治疗14 d后总有效率、尿量、电解质及pro-BNP的差别。结果①试验组总有效率为89.66%,显著高于对照组(77.01%),差异有统计学意义(χ2=7.968,P=0.019);②两组治疗后尿量较治疗前显著增加,差异有统计学意义(P<0.05),血钾和pro-BNP均较治疗前显著下降,差异有统计学意义(P<0.05);③治疗后试验组尿量和血钾显著高于对照组,差异有统计学意义(P<0.05),pro-BNP显著低于对照组,差异有统计学意义(P<0.05);④试验组总不良反应发生率及低钾血症发生率显著低于对照组,差异有统计学意义(P<0.05)。结论呋塞米与托拉塞米间隔使用可提高CHF治疗的总有效率,增加尿量,减少电解质紊乱等不良反应。Objective To confirm the effect of interval usage of furosemide and torasemide in treatment of chronic heart failure （ CHF）. Methods By simple randomization, the patients were divided into the observe group （ interval usage of furosemide and to- rasemide ） and the control group（continuous usage of furosemide）. The difference of the efficiency, urine volume, electrolytes and pro-BNP were compared between the two groups. Results The efficiency, urine volume and serum potassium were significantly higher in the observed group than that of the control group（ P 〈 0.05 ）. The pro-BNP and the incidence of adverse reactions were significantly lower in the observed group than that of the control group （P 〈 0.05 ）. Conclusion The interval usage of furosemide and torasemide could get better curative effect in treatment of CHF.

关 键 词：呋塞米 托拉塞米 慢性心力衰竭 

分 类 号：R983.1[医药卫生—药品]