植物反应器在动物疫苗研究中的应用  

Plant-Made Vaccines for Animals

作　　者：王淼[1] 王建民 葛云侠[2] 杨艺[1] 史振声[3] 

机构地区：[1]沈阳农业大学畜牧兽医学院,沈阳110866 [2]沈阳农业大学生物科学技术学院,沈阳110866 [3]沈阳农业大学农学院,沈阳110866

出　　处：《湖北农业科学》2012年第16期3425-3426,3439,共3页Hubei Agricultural Sciences

基　　金：辽宁省博士启动基金项目(20101095)

摘　　要：用植物生产像疫苗这样高价值的药用产品,这一概念已经提出了20年。直到现在为止这项技术仍不是十分成熟。最初人们都看好瞬时表达;证实了这种疫苗对人和动物是有效的;有些植物疫苗已经进入了人的Ⅰ期临床试验,还有一些正准备进行;监管的要求比以往更加严格。生产注射用产品可能会比生产可食用疫苗容易。该技术已被证明更廉价,更易于寻找生产材料。由于植物疫苗对于生产抵御引起大流行的病毒快速应答疫苗有无法替代的优势,在未来将会为人类的发展做出巨大的贡献。The concept of using plants to produce high-value pharmaceuticals such as vaccines is 20 years old and is only now on the brink of realisation as an established technology. The original reliance on transgenic plants has largely given way to transient expression; proofs of concept for human and animal vaccines and of efficacy for animal vaccines have been established; several plant-produced vaccines have been through Phase I clinical trials in humans and more are scheduled; regulatory requirements are more clear than ever. The original concept of cheap edible vaccines has given way to a realisation that formulated products are required, which may well be injectable. The technology has proven its worth as a means of cheap, easily scalable production of materials, it now needs to find its niche in competition with established technologies. The realised achievements in the field as well as promising new developments was reviewed, such as rapid-response vaccines for emerging viruses with pandemic potential and bioterror agents.

关 键 词：动物疫苗 植物反应器 转基因植物 转基因表达 

分 类 号：S852.4[农业科学—基础兽医学] Q943.2[农业科学—兽医学]