Slit/Robo信号在血管新生及内皮细胞迁移中作用的研究进展  

Review of Recent Research of Slit/Robo Signal in Angiogenesis and Endothelial Cell Migration

作　　者：倪伟[1,2,3] 王浩宇[1,2,3] 刘涛[1,2,3] 

机构地区：[1]川北医学院第二临床学院 [2]南充市中心医院心内科 [3]川北医学院组织工程与干细胞研究所,四川南充637000

出　　处：《心血管病学进展》2012年第5期670-672,共3页Advances in Cardiovascular Diseases

摘　　要：在研究轴突导向分子Slit及其受体Roundabout(Robo)轴突导向功能过程中,发现Slit/Robo信号同样参与血管新生及内皮细胞迁移的调控。但Slit/Robo信号究竟起抑制还是促进作用目前还存在争议,该文从抑制和促进两方面对Slit/Robo信号在血管新生及内皮细胞迁移中的作用进行综述,以期进一步探讨Slit/Robo信号在该领域的功能研究。In the process of researching axon guidance molecules Slit and its receptor Robo, it was found that the Slit/Robo signal is also involved in the regulation of angiogenesis and endothelial cell migration. It is still unknown, however, whether the Slit/Robo function is to inhibit or to promote. This paper reviews the role of the Slit/Robo signal in angiogenesis and endothelial cell migration from the aspect of inhibition and of promotion.

关 键 词：轴突导向分子 Slit/Robo信号 血管新生 内皮细胞 细胞迁移 

分 类 号：R363[医药卫生—病理学]