硬组织修复材料的骨再生机理研究  

Bone Regeneration Mechanism of Advanced Biomaterials for Hard Tissue Repair

作　　者：邹学农[1] 陈大福[2] 田伟[2] 张西正 吴刚[4] 董华[4] 周永胜[5] 周光前[6] 

机构地区：[1]中山大学附属第一医院骨科研究所,广东广州510080 [2]北京积水潭医院创伤骨科研究所,北京100035 [3]中国人民解放军军事医学科学院卫生装备研究所,天津300161 [4]华南理工大学国家人体组织功能重建工程技术研究中心,广东广州510006 [5]北京大学口腔医院,北京100081 [6]深圳大学医学院,广东深圳518060

出　　处：《中国材料进展》2012年第9期40-50,共11页Materials China

基　　金：科技部973计划项目(2012CB619100);国家自然科学基金资助项目(30571892)

摘　　要：传统硬组织修复材料由于在组成及结构上与人体骨组织存在较大差异,植入体内后的骨组织修复过程基本上是一种被动的"充填"过程,且材料的降解速度与新骨形成速度不匹配,难以达到真正的"生物性融合",严重制约了该类材料在骨科临床的推广应用。因此,设计与制备具有"主动修复功能"和"可调控生物响应特性"的第3代新型硬组织修复材料已成为当前骨科临床的新需求和未来的发展方向。介绍了硬组织修复材料的骨再生机理研究方法,综述了硬组织修复材料与宿主防御和骨再生及宿主微环境对材料与宿主细胞相互作用的研究现状。指出硬组织修复材料植入体内后所发生的序列事件可能通过表观遗传修饰使得基因表达受材料本身和宿主微环境等因素的调控,提出新型硬组织修复材料研究中存在的问题和发展趋势。Traditional biomaterials for hard tissue repair in composition and structure are hugely different with human bone tissue. The repairing process of these materials is basically a passive ＂filling＂ process when implanted in the body. Because new bone formation and material degradation rate do not match well enough, it is difficult to achieve the real ＂bio- logical fusion＂, and this restricted the use of materials in orthopaedic clinical application. Therefore, design and prepara- tion of advanced third generation biomaterials for hard tissue repair with ＂active repair function＂ and ＂controlled biological response characteristics＂ has become the new demand of orthopaedic clinical application and future research direction. This paper introduced main research methods for bone regeneration mechanisms of advanced biomaterials for hard tissue re- pair, and it also summarized the current research results of interactions between these biomaterials and host cells in host microenvironment, and interactions between the biomaterials and host defense responses in the process of bone regenera- tion. These sequential events after the implantation of advanced biomaterials for hard tissue repair are apparently controlled bv ~ene rezulation, which is possible to be modified by a series of epigenetic mechanisms with many factors such as mate-rial itself and host microenvironmental factors. This paper puts forward new problems existed in the research of advanced biomaterials for hard tissue repair and development trend.

关 键 词：硬组织修复材料 骨再生 宿主防御 宿主微环境 表观遗传学 基因调控 

分 类 号：R318.08[医药卫生—生物医学工程]