熊去氧胆酸治疗药物性肝病62例疗效观察  

Therapeutic efficacy of ursodeoxycholic acid for drug-induced liver disease

作　　者：胡兴无[1] 齐昌晋 周红星[1] 

机构地区：[1]黄陂区人民医院感染病区,武汉430300

出　　处：《临床肝胆病杂志》2012年第9期695-696,共2页Journal of Clinical Hepatology

摘　　要：目的观察熊去氧胆酸治疗药物性肝病的临床疗效。方法将我院130例药物性肝病随机分为对照组(68例)和治疗组(62例),对照组给予甘草酸二铵、还原型谷胱甘肽、多烯磷酯酰胆碱,治疗组在对照组的基础上,加用熊去氧胆酸12～15 mg.kg–1.d–1,口服分三次,两组疗程均为4周。监测治疗前,2周、4周肝功能变化和观察临床疗效。结果治疗组在肝功能改善方面明显优于对照组(P<0.01),治疗组和对照组临床疗效比较,差异有统计学意义(P<0.01)。结论熊去氧胆酸治疗药物性肝病确有较好疗效。Objective To observe the clinical efficacy of ursodeoxycholic acid for recovering liver function in patients with drug - induced liver disease. Methods One - hundred - and - thirty patients with drug - induced liver disease were randomly assigned to a control treat- ment group （n = 68 ） or an experimental treatment group （n = 62）. The control group received the standard hepatiniea therapy of diammonium glycyrrhizinate, reduced glutathione, and polyene phosphatidylcholine. The experimental group received ursodeoxyeholic acid at 12 -15 mg·kg^-1 . d^-1 p.O. in three divided doses. The treatment course lasted for four weeks for both groups. Liver function was assessed by serum chemistry prior to treatment initiation, and two and four weeks after treatment completion. Results Liver function improved after treat- ment in both groups, but the ursodeoxyeholic acid treatment group showed significantly more improvement than the standard treatment group （ P 〈 0.01 ）. Conclusion Ursodeoxycholic acid has beneficial therapeutic effect for resolving impaired liver function in drug - induced liver disease and may represent a superior treatment to the traditional hepatinica drugs.

关 键 词：肝炎 中毒性 熊去氧胆酸 

分 类 号：R595.3[医药卫生—内科学]