语言功能脑区功能磁共振可重复性观察  

Study of functional magnetic resonance imaging repeatability of linguistic-functional cortex

作　　者：王美豪[1] 汪娟[2] 黄梓芮[3] 陈兵[4] 戴睿[5] 王维卓[2] 翁旭初[6] 程敬亮[1] 

机构地区：[1]郑州大学第一附属医院磁共振科,450052 [2]温州医学院附属第一医院放射科 [3]中国科学院心理研究所 [4]厦门大学信息科学与技术学院智能科学系 [5]华南师范大学生命科学学院 [6]杭州师范大学教育科学学院

出　　处：《中华医学杂志》2012年第35期2499-2502,共4页National Medical Journal of China

摘　　要：目的运用功能磁共振（fMRD技术，考察参与汉语加工的脑功能区在语言任务中激活的可复制性和稳定性，从而为临床术前定位和失语症神经恢复机制提供依据。方法选用语义判断和语音判断两种语言任务，对15名健康志愿者进行两次相同语言任务的fMRI扫描。通过组分析有效重叠激活图的方法，估计不同被试问语言任务fMRI的可复制性；在个体水平上计算被试前、后两次扫描同一ROI质心坐标的空间距离确定其稳定性。结果语义判断任务在Broca区的可复制性结果最好。个体水平质心坐标空间距离比较，Broca区比Wernicke区稳定性好，语义判断任务在Broca区的稳定性比语音判断任务要好。结论语义判断任务在Broca区的可复制性和稳定性相对要更好，可用于临床相关疾病的术前定位及失语症的语言神经恢复机制的研究。Objective To explore the reproducibility and stability of brain functional area in the response of language tasks during Chinese word processing with functional magnetic resonance imaging （fMRI） by follow-up scanning so as to provide rationales for clinical preoperative localization and the mechanisms of recovery from aphasia. Methods The fMRI data were collected by scanning semantic and phonologic judgments in 15 healthy volunteers. Each subject was scanned twice by the same fMRI procedure of both language tasks with an interval of 1 month. By analyzing the effective overlapping average activation maps, the reproducibility of inter-subject imaging result for two language tasks were estimated by selecting the main language areas, such as Broca＇ s area and Wernicke＇ s area as the region of interest （ROI）. By individually calculating the spatial distance of ROI centroid coordinates in the same activating range before and after test, the inter-subject stability in between-session was calculated quantitatively. Results Both language tasks activated more than one language-related brain areas in cerebral hemispheres. Both language tasks induced significant BOLD response in Broca＇ s and Wernicke＇s areas with a tendency of left lateralization. The number of subjects in terms of the activation of both language tasks in Broca＇ s and Wernicke＇s areas accounted over a half of the total subjects. As compared with the phonologic judgment task, the semantic judgment task showed better reproducibility in Broca＇s area. In the same spatial distance of ROI centroid coordinates, the stability of Broca＇s area was higher than that of Wernicke＇s area while the stability of semantic judgment in Broca＇ s area higher than that of phonologic judgment. Conclusion Such main language domains as Broca＇s and Wernicke＇s areas can be effectively activated by both semantic and phonologic judgments. By comparison, semantic ）udgment in Broca＇ s area shows a higher level of reproducibility and stability. Thus it is

关 键 词：磁共振成像 语言 可重复性 结果 BROCA区 

分 类 号：R445.2[医药卫生—影像医学与核医学]