血浆D-二聚体和纤维蛋白原水平在恶性肿瘤诊断中的临床意义  

Clinical significance of plasma D-Dimer and Fibrinogen levels in diagnosis of malignancy

作　　者：郑岚[1] 张漩[1] 郑浩[1] 孙涛[2] 

机构地区：[1]安徽省蚌埠市第三人民医院检验科,安徽蚌埠233000 [2]安徽省蚌埠市第三人民医院财务科,安徽蚌埠233000

出　　处：《蚌埠医学院学报》2012年第10期1235-1237,共3页Journal of Bengbu Medical College

摘　　要：目的:探讨恶性肿瘤患者血浆D-二聚体(DD)和纤维蛋白原(Fib)水平测定的临床意义。方法:采用德国产Sysmex CA-1500型全自动血凝仪检测60例常见恶性肿瘤患者以及30名健康对照组受试者血浆DD、Fib。结果:恶性肿瘤患者较正常对照组血浆DD和Fib水平明显升高(P<0.05)。常见5种恶性肿瘤之间血浆DD和Fib阳性率差异无统计学意义(P>0.05),与对照组比较差异有统计学意义(P<0.05)。结论:恶性肿瘤患者有不同程度的继发性纤溶存在,血浆DD和Fib指标有助于恶性肿瘤的诊断。Objective： To study the clinical significance of plasma D-dimer and fibrinogen levels in diagnosis of malignancy.Methods：The plasma D-dimer and fibrinogen levels were tested in 60 common malignancy patients and 30 healthy cases as control by German Sysmex CA-1500 auto coagulative instrument. Results：Compared with control group,the plasma D-dimer and fibrinogen levels in malignancy patients＇ were increased obviously（ P 〈 0.01 ）. There was no statistical difference about plasma D-dimer and fibrinogen positive rates among the common five cancers （ P 〉 0.05 ）, but had significant difference with control group （ P 〈 0.05 ）. Conclusions ： Malignancy patients have the secondary different degree of fibrinolysis, plasma D-dimer and fibrinogen levels are able to facilitate the diagnosis of malignancy.

关 键 词：纤维蛋白原 D-二聚体 恶性肿瘤 

分 类 号：R977.6[医药卫生—药品]