促红细胞生成素在老年慢性心力衰竭患者中的应用效果观察  

Effect of erythropoietin in the treatment of elderly patient with chronic heart failure

作　　者：郭玲[1] 许崇恩[2] 吕琳[1] 王爱红[1] 

机构地区：[1]山东大学附属省立医院心内科,山东济南200021 [2]山东大学附属省立医院心外科,山东济南200021

出　　处：《海南医学》2012年第19期4-6,共3页Hainan Medical Journal

基　　金：山东省自然基金项目(编号:Y2007C052)

摘　　要：目的探讨促红细胞生成素(EPO)治疗慢性心力衰竭(CHF)老年患者的临床效果。方法 80例CHF老年患者随机分为观察组和对照组各40例,对照组给予血管紧张素转换酶抑制剂、地高辛、利尿剂、β阻滞剂等药物口服治疗,观察组在以上基础上应用EPO皮下注射治疗,对两组临床结果进行比较分析。结果观察组治疗后与治疗前相比,心功能分级、心肌耗氧量峰值、LVEF、血红蛋白、6min步行距离均有显著改善,差异有统计学意义(P<0.05),治疗结果明显优于对照组。观察组死亡1例,死亡原因为猝死。对照组死亡4例,死亡原因为脑血管意外、CHF和猝死。结论 EPO对CHF老年患者的红细胞生成起到促进作用,还可以改善CHF能量代谢和患者的心功能分级,起到心血管保护作用。Objective To investigate the clinical effect of erythropoietin （EPO） for treating elderly patients with chronic heart failure （CHF）. Methods Eighty elderly patients with CHF were randomly divided into the obser- vation group and the control group, with 40 patients in each group. Patients in the control group were given oral treat- ment of angiotensin converting enzyme inhibitors, digoxin, diuretics, fl blocker. Patients in observation group were giv- en subcutaneous injection of EPO on the basis of the treatment of the control group. The clinical results of the two groups were comparatively analyzed. Results In the observation group, the cardiac function, myocardial oxygen con- sumption peak, LVEF, hemoglobin, 6 min walking distance after treatment were significantly improved, compared with those before treatment （P〈0.05）. The results of the observation group were significantly better than that of the control group. One patient in the observation group died because of sudden death, while 4 patients in the control group died because of cerebral vascular accident, CI-IF and sudden death. Conclusion EPO plays a catalytic role for the for- mation of red blood cells, which can also improve the energy metabolism and cardiac function grading, and protect the cardiovascular in elderly patient with CHF.

关 键 词：慢性心力衰竭 促红细胞生成素 老年患者 

分 类 号：R541.6[医药卫生—心血管疾病]