Myelopoiesis during Zebrafish Early Development  

作　　者：Jin Xu Linsen Du Zilong Wen 

机构地区：[1]State Key Laboratory of Molecular Neuroscience,Division of Life Science,Hong Kong University of Science and Technology,Clear Water Bay,Kowloon,Hong Kong,China [2]Cancer Science Institute of Singapore,National University of Singapore,14 Medical Drive,#12-01,Singapore 117599,Singapore

出　　处：《Journal of Genetics and Genomics》2012年第9期435-442,共8页遗传学报（英文版）

基　　金：supported by a grant from the Research Grants Council of the HKSAR(No.HKUST6/CRF/09)

摘　　要：Myelopoiesis is the process of producing all types of myeloid cells including monocytes/macrophages and granulocytes.Myeloid cells are known to manifest a wide spectrum of activities such as immune surveillance and tissue remodeling.Irregularities in myeloid cell development and their function are known to associate with the onset and the progression of a variety of human disorders such as leukemia.In the past decades,extensive studies have been carried out in various model organisms to elucidate the molecular mechanisms underlying myelopoiesis with the hope that these efforts will yield knowledge translatable into therapies for related diseases.Zebrafish has recently emerged as a prominent animal model for studying myelopoiesis,especially during early embryogenesis,largely owing to its unique properties such as transparent embryonic body and external development.This review introduces the methodologies used in zebrafish research and focuses on the recent research progresses of zebrafish myelopoiesis.Myelopoiesis is the process of producing all types of myeloid cells including monocytes/macrophages and granulocytes.Myeloid cells are known to manifest a wide spectrum of activities such as immune surveillance and tissue remodeling.Irregularities in myeloid cell development and their function are known to associate with the onset and the progression of a variety of human disorders such as leukemia.In the past decades,extensive studies have been carried out in various model organisms to elucidate the molecular mechanisms underlying myelopoiesis with the hope that these efforts will yield knowledge translatable into therapies for related diseases.Zebrafish has recently emerged as a prominent animal model for studying myelopoiesis,especially during early embryogenesis,largely owing to its unique properties such as transparent embryonic body and external development.This review introduces the methodologies used in zebrafish research and focuses on the recent research progresses of zebrafish myelopoiesis.

关 键 词：Zebrafish Hematopoiesis Myelopoiesis 

分 类 号：Q954.4[生物学—动物学] S896.3[农业科学—特种经济动物饲养]