HIGH IMMOBILIZATION OF ANTIBACTERIAL MOIETIES ONTO MONODISPERSE MICROSPHERES BY DISPERSION POLYMERIZATION USING BICATIONIC VIOLOGEN SURFMER  

作　　者：刘莲英 杨万泰 

机构地区：[1]Key Laboratory of Carbon Fiber and Functional Polymers,Ministry of Education,College of Materials Science and Engineering,Beijing University of Chemical Technology

出　　处：《Chinese Journal of Polymer Science》2012年第6期865-872,共8页高分子科学（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.20974008)

摘　　要：In order to achieve monodisperse particles with high content of antibacterial groups covalently bonded on surface, a bicationie viologen, N-hexyl-N-（4-vinylbenzyl）-4,4＇-bipyridinium bromide chloride （HVV） was devised as a surfrner in dispersion polymerization of styrene （St） using a mixture of methanol （or ethylene glycol） and water as media. Effects of content of HVV, its addition profile and composition of reaction media on particles size and incorporation of HVV moieties were mainly investigated. The attachment of silver and gold nanoparticles on particle surface under UV irradiation ascertained the surface-bonded HVV segments. SEM, TEM observations and XPS, zata potential measurements indicated that increase of initial HVV contents and addition of HVV （when polymerization had been performed for 3 h） led to grown particles and enhanced immobilization of HVV moieties. Using a mixture of ethylene glycol and water as reaction media, small particles （520-142 nm） with highly attached HVV moieties were prepared. Furthermore, antibacterial efficacy of the resultant particles against S. aureus was assayed, and particles with more HVV moieties anchored on surface demonstrated greater efficiency of antibacterial activity.In order to achieve monodisperse particles with high content of antibacterial groups covalently bonded on surface, a bicationie viologen, N-hexyl-N-（4-vinylbenzyl）-4,4＇-bipyridinium bromide chloride （HVV） was devised as a surfrner in dispersion polymerization of styrene （St） using a mixture of methanol （or ethylene glycol） and water as media. Effects of content of HVV, its addition profile and composition of reaction media on particles size and incorporation of HVV moieties were mainly investigated. The attachment of silver and gold nanoparticles on particle surface under UV irradiation ascertained the surface-bonded HVV segments. SEM, TEM observations and XPS, zata potential measurements indicated that increase of initial HVV contents and addition of HVV （when polymerization had been performed for 3 h） led to grown particles and enhanced immobilization of HVV moieties. Using a mixture of ethylene glycol and water as reaction media, small particles （520-142 nm） with highly attached HVV moieties were prepared. Furthermore, antibacterial efficacy of the resultant particles against S. aureus was assayed, and particles with more HVV moieties anchored on surface demonstrated greater efficiency of antibacterial activity.

关 键 词：Antibacterial microsphere MONODISPERSITY Dispersion polymerization VIOLOGEN Surfmer. 

分 类 号：O621.2[理学—有机化学]