七氟醚与丙泊酚对老年全麻患者血流动力学的影响比较  

Effects of sevoflurane and propofol in elderly patients undergoing general anesthesia comparison of hemodynamic effects

作　　者：杨洪宝[1] 

机构地区：[1]山东省高唐县人民医院麻醉科,252800

出　　处：《中国实用医药》2012年第26期15-16,共2页China Practical Medicine

摘　　要：目的探讨七氟醚与丙泊酚对老年全麻患者血流动力学的影响及心肌保护作用的比较。方法 将100例老年急症全麻手术患者法随机分为丙泊酚组50例(P组)和七氟醚组50例(S组)。S组从手术开始直至结束全程吸入最低肺泡有效浓度七氟醚,P组则靶控泵入3μg/ml的丙泊酚。检测术前、术中0.5h、1h、1.5h、术后2h、4h两组血浆心肌肌酸激酶同工酶(CK-MB)、肌钙蛋白I(cTnl)水平变化并同时监测记录HR、MAP、CVP。结果 两组术前、术中0.5h,血浆CK-MB、cTnl、HR、MAP、CVP水平均升高(t=4.54、4.61、4.71、4.84、4.89,P<0.05,差异具有统计学意义),术中1h、1.5h、术后2h、4h,S组优于P组(t=4.66、4.67、4.78、5.56、5.66,P<0.05,差异具有统计学意义)。结论 七氟醚较丙泊酚在老年急症全麻下手术心肌保护作用血流动力学稳定均较丙泊酚效果为好。Objective To investigate the sevoflurane and propofol in elderly patients undergoing gener- al anesthesia hemodynamics and myocardial protective effects of comparison. Methods 100 cases of elderly patients with acute general anesthesia operation simple randomization randomized to propofol group （ P group） andS0 cases of sevoflurane group in 50 cases （group S）. S group from the beginning of operation until the end of the whole minimum alveolar concentration of sevoflurane inhalation, while group P target-controlled pump into 3UG / ml propofol. Detection of preoperative, intraoperative 0. 5 h, 1 h, 1.5 h,2 h,4 h after operation in the two groups of myocardial creatine kinase isoenzyme （CK-MB）, cardiac troponin I （cTnl） level and at the same time monitoring and recording HR, MAP, CVP. Results Two groups of preoperative, intraoperative 0.5 h, plasma CK-MB, cTnl, HR, MAP, CVP levels were elevated （ t = 4. 54,4. 61 ,d. 71,4. 84,4. 89, P 〈 0.05, with significant difference）, intraoperative 1 h, 1.5 h, 2 h, 4 h after surgery, S group than in P group （ t = 4. 66,4. 67,4,78,5.56,5.66, P 〈 0.05, with significant difference）. Conclusion Sevoflurane than propofol in elderly patients under general anesthesia operation myocardial protective effects of propofol on hemodynamic stability were compared as well.

关 键 词：七氟醚 丙泊酚 血流动力学 比较 

分 类 号：R614[医药卫生—麻醉学]