肝动脉化疗栓塞术对乙肝病毒再激活的影响及拉米夫定对乙肝病毒再激活的作用  

The impact of transcatheter arterial chemoembolization on hepatitis B virus reactivation and the effect of lamivudine on the hepatitis B virus reactivation

作　　者：庞桦进[1] 李彦豪[1] 顾小媛[1] 杨旸[1] 何晓峰[1] 

机构地区：[1]南方医科大学附属南方医院介入诊疗科,广东广州510515

出　　处：《西部医学》2012年第9期1728-1729,1732,共3页Medical Journal of West China

摘　　要：目的探讨肝动脉化疗栓塞术(TACE)对乙肝病毒再激活患者的影响及拉米夫定对乙肝病毒再激活的预防作用。方法将66例行TACE术治疗的HBV相关肝癌病人按有无服用拉米夫定分为TACE治疗组33例(单纯组)和拉米夫定联合TACE治疗组33例(联合组)。对这些患者栓塞术前、术后的乙肝病毒定量进行分析,并观察拉米夫定对乙肝病毒再激活的作用。结果单纯TACE组中,乙肝病毒再激活率为36.4%,联合组中,HBV再激活率为15.2%。两组相比,有统计学意义(P<0.05)。结论 TACE会导致HBV的再激活,出现肝炎活动。拉米夫定可预防TACE后的HBV再激活。HBeAg(+)可作为提示HBV再激活的一个指标。Objective To probe into the impact of transcatheter arterial chemoembolization on hepatitis B virus reactivation and the efficacy of lamivudine in preventing HBV reactivation.Methods 66 hospitalized patients with HCC of HBV were divided into TACE group（n=33,control group） and TACE plus lamivudine group（n=33,therapeutic group）.Analyze the patients＇ HBV ration before and after surgery,and observe the efficacy of lamivudine in preventing HBV reactivation.Results The percentage of HBV reactivation is 36.4 in TACE group while 15.2 in the other group.The comparison of two groups is meaningful in Statistics（P0.05）.Conclusion TACE would lead to HBV reactivation and hepatitis.Lamivudine could prevent HBV reactivation after TACE.HBeAg（＋）could be viewed as a reference point for HBV reactivation.

关 键 词：肝炎病毒 乙型 拉米夫定 栓塞 再激活 

分 类 号：R512.62[医药卫生—内科学]