茶碱缓释片联合短期甲基泼尼松龙治疗支气管哮喘急性发作的临床观察  

The clinical effect of sustained release tablets of theophylline combined with methylprednisolone on treatment of bronchial asthma

作　　者：冯志祥[1] 周华娟[1] 胡少华[1] 

机构地区：[1]浙江省杭州市余杭区第五人民医院内科,杭州311100

出　　处：《海峡药学》2012年第8期92-94,共3页Strait Pharmaceutical Journal

摘　　要：目的比较茶碱缓释片(舒弗美)单独与联合短期甲基泼尼松龙(甲强龙)对支气管哮喘急性发作治疗的临床效果。方法将78例临床确诊为支气管哮喘急性发作的患者随机分为两组,每组39例,治疗组接受茶碱缓释片(舒弗美)联合甲基泼尼松龙治疗,对照组单独接受舒弗美治疗。比较用药前、用药3天后两组患者肺功能及临床症状改善情况。结果治疗组临床控制26例,显效7例,有效4例,无效2例,总有效率94.9%;对照组临床控制24例,显效8例,有效3例,无效4例,总有效率89.7%;总有效率两组比较差异无统计学意义(χ2=0.675,P=0.377)。在胸闷、呼吸困难及低氧等症状评分减少方面,治疗组优于对照组(93.7±14.3 vs 82.1±14.8,P=0.025)。在肺功能方面,两组治疗后较治疗前均有改善,但治疗组FVC改善更明显(1.52±0.51 vs 2.01±0.45,P=0.044)。结论舒弗美联合短期甲强龙可明显改善支气管哮喘患者的气道阻塞,缓解临床症状,缩短住院时间,疗效显著。OBJECTIVE To investigate the effcet of theophylline combined with methylprednisolone on treatment of bronchial asthma.METHODS 78 patients with bronchial asthma were randomly divided into treatment group and control group.The former was taken theophylline and methylprednisolone treatment while the later single theophylline treatment.RESULTS The total effective rate for the treatment group was 94.9% compared with 89.7% in control group which was not statistically different.In the aspect of pulmonary function and syndrom improvement,treatment group was prior to control group such as FVC.CONCLUSION The effect of theophylline combined with methylprednisolone on bronchial asthma is effective by improving airway obstruction and clinical syndrom.

关 键 词：舒弗美 甲基泼尼松龙 支气管哮喘 

分 类 号：R969.4[医药卫生—药理学]