电针治疗坐骨神经痛疗效与细胞免疫调节因子变化相关分析  

Correlation Analysis of Electro-acupuncture Effect and Immune Regulators in Treatment of Sciatica

作　　者：任昶[1] 高永辉[2] 耿福太[1] 刘俊岭[2] 李建辉[1] 

机构地区：[1]首都医科大学附属北京朝阳医院,北京100043 [2]中国中医科学院针灸研究所,北京100700

出　　处：《中国中医药信息杂志》2012年第9期11-14,共4页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：国家自然科学基金(81102647);北京市中医药科技项目(JJ2009-24)

摘　　要：目的观察电针治疗坐骨神经痛疗效产生的规律,分析辨证分型、电针疗效与部分细胞免疫调节因子变化的相关性。方法 105例腰椎间盘突出型坐骨神经痛患者电针双侧夹脊穴及患侧环跳、委中穴,疗程14 d。在治疗前对患者进行中医辨证分型,在治疗的过程中检测患者外周血中相关致痛物质及部分免疫因子的变化,分析中医辨证分型、生物学指标的变化与疗效的关系。结果 105例腰椎间盘突出型坐骨神经痛患者,经电针治疗有效82例(78.10%),无效23例(21.90%)。无效组的病程长于有效组(P<0.05),且无效组肝肾两虚型患者多于有效组(P<0.05)。在治疗第2日时,有效组改良日本骨科学会下腰痛评分(M-J0A)改善率即明显增加,至第5日时,白细胞介素-2(IL-2)明显增高,皮质醇(COR)明显降低,与治疗前比较,P<0.05。无效组IL-2和COR的变化不明显(P>0.05)。相关分析显示,M-J0A改善率与IL-2的变化呈正相关,与COR的变化呈负相关(P<0.05)。结论电针治疗坐骨神经痛有较好的疗效,这种疗效与坐骨神经痛患者的病程、中医辨证分型以及治疗早期IL-2和COR的变化有关。Objective To observe the regularity of electro-acupuncture effect in the treatment of sciatica, analyze the correlation of electro-acupuncture effect, TCM syndrome and immune regulators in the treatment of sciatica. Methods A total of 105 sciatica patients were treated by electro-acupuncture on bilateral Jiaji （EX-B2）, and Huantiao （GB30） and Weizhong （BL39） on the affected side. The patients were classified according to TCM syndromes before treatment. During the treatment, some immune regulators were detected and the relation between electro-acupuncture effect of sciatica and changes of immune regulators were analyzed. Results After treatment, among 105 sciatica patients, 82 cases （78.10%） were effective and 23 cases （21.90%） were ineffective. The disease course of ineffective group was longer than the effective group, and cases of deficiency syndrome of liver and kidney were more than those in effective group. At the treatment of day 2, modified Japanese Orthopaedics Association Low Back Pain Score （M-JOA） of effective group was improved significantly. After treated for 5 days, interleukin-2 （IL-2） increased and cortisol （COR） decreased in the effective group. The improvement rate of M-JOA was positively related with IL-2 level and negetively related with COR level （P〈0.05）. Conclusion Electro-acupuncture had effective results on treatment of sciatica. The effective result was related with IL-2, COR, course of the disease and TCM syndrome.

关 键 词：电针 坐骨神经痛 辨证分型 白细胞介素-2 皮质醇 

分 类 号：R277.754.2[医药卫生—中医学]