气相色谱法测定同仁牛黄清心丸中麝香酮的含量  

Determination of Muscone in Tongren Niuhuang Qingxin Pills by GC

作　　者：蒋受军 王成芳[2] 刘子沐[2] 杜树山[2] 

机构地区：[1]广西玉林食品药品检验所,广西玉林537000 [2]北京师范大学资源学院教育部资源药物工程研究中心,北京100875

出　　处：《中国中医药信息杂志》2012年第9期64-65,共2页Chinese Journal of Information on Traditional Chinese Medicine

基　　金：北京教育委员会共建项目建设计划(SYS100270430)

摘　　要：目的建立同仁牛黄清心丸中麝香酮的气相色谱(GC)含量测定方法。方法色谱柱为HP-5柱(30 mm×32 mm,25μm),载气为氮气,流速1.0 mL/min,柱温190℃,进样口温度250℃,氢火焰离子化检测器温度220℃。结果麝香酮进样量在0.12～0.28μg(r=0.999 1)范围内,麝香酮峰面积与进样量呈现良好的线性关系,平均加样回收率为98.72%,RSD=2.34%。结论该方法快速、简便、准确、重复性较好,结果可靠,可用于控制同仁牛黄清心丸制剂的质量。Objective To establish an accurate method for the determination of Muscone in Tongren Niuhuang Qingxin Pills by GC. Methods HP-5 column （30 mm×32 mm, 25 μm） in an oven at 190 ℃ was need, inlet temperature was 250 ℃ and FID detector was used with 220 ℃, using nitrogen as the carrier gas. Results The linear range of Muscone was 0.12--0.28 μg （r =0.999 1）. The average recovery was above 98.72% （RSD=2.34%）. Conclusion The method is simple and accurate with good reprodicibility, and can be used for the quality control of Tongren Niuhuang Qingxin Pills.

关 键 词：同仁牛黄清心丸 麝香酮 气相色谱法 含量测定 

分 类 号：R284.1[医药卫生—中药学]