阿替普酶与尿激酶治疗急性心肌梗死患者的临床疗效分析  

A Comparative Study of the Clinical Efficacy of Alteplase and Urokinase on Acute Myocardial Infarction

作　　者：游波[1] 

机构地区：[1]成都市第六人民医院心内科,成都610051

出　　处：《医学综述》2012年第17期2883-2884,2889,共3页Medical Recapitulate

摘　　要：目的探讨阿替普酶与尿激酶治疗急性心肌梗死患者的疗效差异。方法将156例急性心肌梗死患者随机分为两组,各78例,对照组给予小剂量阿替普酶进行治疗,试验组给予尿激酶静脉溶栓治疗。观察两组患者的临床疗效和并发症发生情况。结果试验组总有效率明显高于对照组(96.15%vs 84.62%),差异有统计学意义(P<0.05);对照组患者出院前并发症发生率方面明显高于试验组,试验组患者临床症状缓解和冠状动脉再通方面优于对照组,差异有统计学意义(P<0.05)。结论阿替普酶溶栓治疗急性心肌梗死疗效确切,冠状动脉再通率高、临床疗效好、不良反应少,值得进一步推广使用。Objective To investigate the clinical efficacy of alteplase and urokinase for acute myocardial infarction. Methods 156 cases of acute myocardial infarction were collected, then randomly divided into the control group（78 cases）and observation group（78 cases） ;the control group was given small dose of alteplase, while the observation group was given urokinase. The clinical efficacy and complications of the two groups were observed. Results The total efficacy was higher in the observation group than the control group（96.15% vs 84.62% ） with statistical significance （ P 〈 0.05 ） ; the complication rate before discharge was higher in the control group than the observation group （P 〈 0. 05 ） ; the clinical symptoms improvement rate and coronary ar- tery reconstruction rate in the observation group was higher than the control group（ P 〈 0.05 ）. Conclusion Alteplase can obtain satisfactory curative effect for acute myocardial infarction, featured with high coronary ar- tery reconstruction rate and clinical symptoms improvement rate andt less adverse reactions, thus is worthy of further clinical application.

关 键 词：阿替普酶 尿激酶 急性心肌梗死 临床疗效 

分 类 号：R542.2[医药卫生—心血管疾病]