2007～2011年医院住院患者抗生素应用对比分析  

Application situation of antibiotics in our hospital between 2007 and 2011

作　　者：卜巨源[1] 毛盛名[2] 邹劲林[1] 

机构地区：[1]中山大学附属第五医院普外一科,珠海519000 [2]暨南大学附属第五医院普外科

出　　处：《中华普通外科学文献（电子版）》2012年第4期7-10,共4页Chinese Archives of General Surgery(Electronic Edition)

摘　　要：目的探讨加强医院抗生素管理,控制院内感染和细菌耐药的临床意义。方法在实施严格监管抗生素使用前后随机各抽取500例次住院患者分别作为对照组(2007年1月1日至2009年12月31日)和研究组(2010年1月1日至2011年12月31日),比较两组抗生素使用率、医院感染率和多重耐药率等。结果研究组抗生素使用率(42.8%)、高级抗生素使用率(21.0%)、联合使用使用率(13.6%)均明显低于对照组(分别为69.8%、43.4%和45.4%)(P<0.05);研究组Ⅰ类手术切口的抗生素使用率(17.3%)、使用时间超过5 d的构成比(4.1%)均低于对照组的67.8%和64.5%(P<0.05),但是两组Ⅰ类切口感染率差异无统计学意义;研究组医院感染现患率(5.8%)和多重耐药率(6.6%)均低于对照组的9.6%和11.4%,主要表现在呼吸道感染率的差异显著;多重耐药两组中只有肺炎克雷伯菌感染率差异有统计学意义(P<0.05)。结论临床工作中必须重视住院患者不合理应用抗生素现象。加强抗生素的使用管理能有效降低抗生素使用率,控制院内感染和细菌耐药,节约医疗资源和成本。Objective To explore clinical significance of strengthen the management of hospital antibiotics.Methods Five hundred cases were random chosen respectively from the hospitalized patients before and after management as control group and the study group.It was compared that two sets of antibiotics usage,hospital touching rate and the multiple resistance,et al.Results The antibiotics usage （42.8%）,senior antibiotics utilization rate（21.0%）,combination utilization rate（13.6%） in the study group were significantly lower than those of the control group（69.8%,43.4%and 45.4%,respectively） （P〈0.05）.In I type incision,the antibiotics utilization rate（17.3%） or the constituent ratio of utilization time more than 5 days（4.1%） in the study group were lower than those of the control group（67.8%and 64.5%,P〈0.05 ）,but the incision infection rates of the two groups had no significant difference.The hospital infection rate（5.8%） and multiple rate（6.6%） in study group were lower than those of the control group（9.6%and 11.4%）（P〈0.05）.The hospital infection with respiratory tract infection rate was the most and significant differences between the two groups（P〈0.05）.Multiple resistance in both groups only Klebsiella pneumoniae infection rate existed difference（P〈0.05）.Conclusions The phenomenon of irrational use of antibiotics in hospitalized patients must be paid attention in clinical work.Strengthen the management of the use of antibiotics can effectively reduce the use of antibiotics,control of nosocomial infections and bacterial drug resistance,save medical resources and cost.

关 键 词：抗生素 医院感染 耐药 对比分析 

分 类 号：R95[医药卫生—药学]