^(131)I治疗甲状腺功能亢进症的疗效观察  

^(131)I Therapy for Hyperthyroidism

作　　者：宋效成[1] 凌桂梅[2] 谢秋平[1] 

机构地区：[1]中国人民解放军第413医院内分泌科,浙江舟山316000 [2]百色市人民医院中医科,广西百色533000

出　　处：《实用临床医学（江西）》2012年第7期3-5,共3页Practical Clinical Medicine

摘　　要：目的比较131I与抗甲状腺药物(ATD)治疗甲状腺功能亢进症(简称甲亢)的疗效。方法将180例初诊甲亢患者按随机数字表法分为131I治疗组和ATD治疗组,各组90例。31I治疗组采用131I治疗,ATD治疗组采用丙基硫氧嘧啶或甲硫咪唑治疗。2组均治疗、观察2年以上。观察2组患者治疗后甲减、突眼及甲亢复发的情况、甲亢并发症的疗效和不良反应。结果131I治疗组的治愈率高于ATD治疗组,复发率及不良反应发生率均低于ATD治疗组(均P<0.05),但131I治疗组甲减发生率高于ATD治疗组,甲亢性心脏病的疗效明显优于ATD治疗组(均P<0.05)。结论131I治疗甲亢是相对安全、有效的,其综合疗效优于ATD。Objective To compare the curative effects of 131I and anti-thyroid drugs（ATD） on hyperthyroidism.Methods A total of 180 patients with hyperthyroidism were randomly assigned to receive either 131I therapy（n=90） or ATD treatment（n=90） for more than 2 years.The curative efficacy,hypothyroidism,hyperthyroidism relapse,exophthalmos and adverse reactions were compared between the two groups.Results Compared with ATD treatment group,131I therapy significantly increased curative efficacy and incidence of hypothyroidism,but obviously decreased hyperthyroidism relapse and adverse reactions（all P〈0.05）.In addition,131I was superior to ATD for treating hyperthyroid heart disease（P〈0.05）.Conclusion 131I therapy is safer and more effective than ATD treatment for hyperthyroidism.

关 键 词：甲状腺功能亢进症 碘同位素 放射疗法 抗甲状腺药物 

分 类 号：R581.1[医药卫生—内分泌]