1-[3'-(4″-甲氧基苯基)-5'-甲基异噁唑-4'-甲酰基]-4-芳基氨基硫脲及其衍生物的合成  

Synthesis of 1-[3′-(4″-Methoxyphenyl)-5′-methylisoxazole-4′formyl]-4-arylthiosemicarbazides and Its Derivatives

作　　者：阿布拉江·克依木[1] 阿娜姑·托合提[1] 刘方明[2] 

机构地区：[1]新疆大学化学与化工学院,新疆乌鲁木齐830046 [2]杭州师范大学材料与化学化工学院,浙江杭州310036

出　　处：《合成化学》2012年第5期591-595,共5页Chinese Journal of Synthetic Chemistry

基　　金：新疆自然科学基金资助项目(2009211A02)

摘　　要：以3,5-二取代异噁唑-4-甲酰肼为基本原料制备关键中间体1-(3-对甲氧基苯基-5-甲基异噁唑-4-基)-4-芳基氨基硫脲(3a～3c);3在不同条件下经关环反应制得含有3,5-二取代异噁唑的2-芳氨基噻二唑(4a～4c),2-芳氨基噁二唑(5a～5c)和3-[3'-(4″-甲氧基苯基)-5'-甲基-异噁唑-4'-基)-4-芳基-1,2,4-三唑-5-硫酮(6a～6c);6与碘甲(乙)烷反应合成了4-芳基-5-[3'-(4″-甲氧基苯基)-5'-甲基异噁唑-4'-基]-3-甲(乙)硫基-1,2,4-三唑(7a～8c),其结构经1H NMR,IR,MS和元素分析表征,其中4,5,7和8未见文献报道。Key intermediate,1-（3-p-methoxyphenyl-5-methylisoxazole-4-yl）-4-arylthiosemicarbazides（3a～3c）,were prepared by the reaction of 3,5-disubstituted isoxazole-4-formylhidrizine with arylisothiocyanates.1,3,4-Thiadiazole（4a～4c）,1,3,4-oxadiazole（5a～5c） and the corresponding 5-methyl/ethylthiotriazole（6a～6c） were synthesized by the cyclization of 3 in different reaction conditions.5-Methyl/ethylthiotriazole derivatives（7a～8c） were synthesized by the reaction of 6 with MeI or EtI.The structures were characterized by 1H NMR,IR,MS and elemental analysis.4,5,7 and 8 were new compound.

关 键 词：异噁唑 芳氨基硫脲 1 3 4-噻二唑 1 3 4-噁二唑 烷硫基-1 2 4-三唑 合成 

分 类 号：O626[理学—有机化学]