氧氟沙星-壳聚糖-明胶共混膜的制备及表征  

Preparation and Characterization of the Blended Membranes of Ofloxacin-Chitosan-Gelatin

作　　者：彭湘红[1] 王敏娟[1] 陆茜[1] 李忠铭[1] 杜金萍 王燕[2] 

机构地区：[1]华中理工大学汉口分校化工系,湖北武汉430012 [2]长江科学院新材料室,湖北武汉430010

出　　处：《精细化工》2000年第6期325-327,共3页Fine Chemicals

摘　　要：制备了壳聚糖 明胶共混膜 ,测定了壳聚糖 明胶共混膜的抗张强度 ,并以抗张强度最大的壳聚糖 明胶共混膜为载体 ,氧氟沙星为模型药物制得具有抗菌性能的氧氟沙星 -壳聚糖 -明胶共混膜。通过红外光谱 (FT -IR) ,X射线衍射 (X ray) ,扫描电子显微镜 (SEM)表征了共混膜的特性。结果表明 :明胶质量分数为 2 5 %时 ,壳聚糖 明胶共混膜的抗张强度最大 ,达 5 5MPa。壳聚糖、明胶、氧氟沙星三者在共混膜中有很好的相容性 。The chitosan/gelatin(CSG) and ofloxacinchitosangelatin(CSGF) blended membranes were prepared.The tensile strength of CSG were also determined.IR,Xray diffraction,and SEM were used to characterize the structure of the blended membranes.The results indicated that intermolecular hydrogen bond was formed and there was good compatibility among chitosan,gelatin and ofloxacin moleculars in the blended membranes.When the mass percent of gelatin was 25%,the tensile strength of CSG attained the highest value 55 MPa.

关 键 词：壳聚糖 明胶 氧氟沙星 共混膜 生物材料 

分 类 号：R318.08[医药卫生—生物医学工程] Q73[医药卫生—基础医学]