α-硫辛酸联合甲钴胺治疗糖尿病周围神经病变疗效评估  

作　　者：王祥香[1] 陈德志[1] 王昭玲[1] 火焱 蔡若男[1] 

机构地区：[1]江苏省徐州市第一人民医院内分泌科,221002

出　　处：《浙江临床医学》2012年第9期1063-1065,共3页Zhejiang Clinical Medical Journal

摘　　要：目的评估a-硫辛酸联合甲钻胺治疗糖尿病周围神经病变的临床疗效。方法选择并发糖尿病周围神经病变的2型糖尿病患者90例，分为甲钴胺组、硫辛酸组、硫辛酸联合甲钴胺组，每组各30例，分别予静脉应用甲钴胺、硫辛酸或硫辛酸联合甲钴胺治疗。3周为1个疗程。观察治疗1周、2周、3周后的神经症状总评分（TSS）的变化，并观察治疗前后神经传导速度的变化。结果治疗3周后三组TSS评分及神经传导速度均较治疗前明显改善，硫辛酸组TSS评分下降较甲钴胺组明显，联合治疗组的TSS评分下降及神经传导速度增加较甲钴胺组及硫辛酸组更显著。结论a-硫辛酸和甲钴胺联合用药能有效地改善糖尿病周围神经病变的的症状及神经传导速度，且明显优于单一用药。Objective To investigate the Clinical efficacy of alpha-lipoic acid （ ALA ） and mecobalamin in treating diabetic peripheral neuropathy. Methods Ninety type 2 diabetic patients complicated with diabetic peripheral neuropathy were divided into 3 groups for treatment with mecobalamin, ALA or ALA and mecobalamin for 3 weeks. The total symptoms score （ TSS ） were used to evaluate the nervous symptoms at zero point and after treatment for 1, 2, 3 weeks separately. The nerve conduction velocity was detected with electromyography before and after the treatment. Results The TSS was significantly diminished and the nerve conduction velocity was accelerated than those before treatment in the three groups after 3 weeks. There was a significant decrease in TSS in the ALA group versus the mecobalamin group. The ALA and mecobalamin group was better than the two other groups in reducing the TSS and in accelerating the nerve conduction velocity. Conclusions The treatment with ALA and mecobalamin effectively improves the sensitive symptoms and the nerve conduction velocity of diabetic peripheral neuropathy. The curative effect is better than ALA or mecobalamin alone.

关 键 词：糖尿病周围神经病变 硫辛酸 甲钴胺 

分 类 号：R587.2[医药卫生—内分泌]