耐药突变选择窗与抗菌药物防耐药突变浓度的研究进展  

Research of Mutant Prevention Concentration and Mutant Selection Window

作　　者：刘淼[1] 刘海凤[2] 郑风劲[1] 

机构地区：[1]四川大学基础医学与法医学院,成都610041 [2]新乡医学院第三附属医院,新乡453003

出　　处：《四川解剖学杂志》2012年第2期55-58,共4页Sichuan Journal of Anatomy

摘　　要：突变选择窗(MSW),是指抗菌药物防止细菌选择第一步耐药突变的最低浓度(防耐药突变浓度,MPC)与最小抑菌浓度(MIC)的浓度范围。当血清或组织液药物浓度低于MIC时,治疗无效但也不会导致细菌耐药突变体的富集;超过MPC时细菌要生长需同时具备两种或以上突变,因而不仅治疗成功并且也很难出现耐药突变体的选择性扩增;处于窗内时将选择出耐药突变菌,尽管临床治疗成功率很高,但会促使细菌耐药性的形成。The mutant selection window（MSW） is an antimicrobial concentration range extending from the the single-step mutant to inhibit the growth of the least susceptible（mutant prevention concentration（MPC））to the minimal concentration（MIC）required to block the growth of wild-type bacteria.When the drug concentration of the blood serum or tissue fluid below the MIC,there will be a Ineffective treatment but it won＇t lead to bacterial drug-resistant mutants enrichment;When the concentration above the MPC,bacterias need two or more steps＇ mutant to grow.,so that the treatment will be successful and the drug-resistant mutants will hatd to arise.Placing antimicrobial concentrations inside the window expected to arise the rate of Clinical cures but would enrich resistant mutant subpopulations selectively and lead to more drug resistance.

关 键 词：突变选择窗 防耐药突变浓度 

分 类 号：R96[医药卫生—药理学]