VEGF和IMT测定对OSAS的临床意义  

The Clinical Significance of VEGF and carotid intima-media thickness in Obstructive sleep apnea syndrome

作　　者：李慧[1] 钟定[1] 李莉[1] 

机构地区：[1]深圳市宝安区人民医院呼吸内科,广东深圳518101

出　　处：《临床肺科杂志》2012年第10期1757-1758,共2页Journal of Clinical Pulmonary Medicine

基　　金：深圳市宝安区科技计划社会公益科研资助项目(2009314)

摘　　要：目的探讨血管内皮生长因子(VEGF)、颈动脉内膜中层厚度(IMT)与OSAS患者的关系。方法选取男性OS-AS患者30例和体检正常者25例进行多导睡眠监测,评估呼吸暂停低通气指数(AHI)、夜间缺氧时间、最低血氧饱和度差异。同时,检测外周血中的VEGF水平和颈动脉内膜中层厚度(IMT),并分析其差异及与睡眠监测指标相关性。结果与对照组比较,OSAS患者呼吸暂停低通气指数(AHI)、夜间缺氧时间、IMT、VEGF较明显增高,最低血氧饱和度明显降低,差异有统计学意义(P均<0.05);相关性分析显示,血浆VEGF与AHI、夜间缺氧时间正相关(P<0.05),与最低血氧饱和度负相关(P<0.05)。颈动脉IMT与AHI正相关(P<0.05),与最低血氧饱和度负相关(P<0.05)。结论 VEGF可能在OSAS患者发病中起重要作用,为早期预防OSAHS患者心血管合并症提供新思路。Objective To explore the relationship between Vascular endothelial growth factor （VEGF）, carotid intima-media thickness （IMT） and Obstructive sleep apnea syndrome （OSAS）. Methods 30 male OSAS patients and 25 cases of normal subjects were selected to conduct sleep apnea monitoring by polysonmography. The level of VEGF in plasma was measured and the carotid IMT was evaluated. Their differences and the correlation with sleep monitoring index were analyzed. Results Compared with the control group, the AHI, hypoxia time at night, VEGF and IMT in OSAS in- creased more obviously, while the Lowest oxygen saturation decreased more obviously, and the differences were statistically significant （ P 〈 0.05 ）. The VEGF positively correlated with AHI, night hypoxia time （ P 〈0. 05 ）, but negatively correlated with lowest oxygen saturation （P 〈 0. 05）. Carotid IMT was positively correlated with AHI （ P 〈 0. 05 ）, and negatively correlation with lowest oxygen saturation （P 〈 0.05）. Conclusion VEGF may play an important role in the pathogenesis of patients with OSAS, which provides new ideas for early prevention OSAS patients with cardiovascular complications.

关 键 词：阻塞性睡眠呼吸暂停综合征 血管内皮生长因子 动脉内膜中层厚度 

分 类 号：R56[医药卫生—呼吸系统]