内源性硫化氢与高原地区慢性肺心病肺动脉高压的相关性研究  

The analysis of the correlation between endogenous hydrogen sulfide and pulmonary arteries hypertension in patients with chronic cor pulmonale at high altitude

作　　者：冯恩志[1] 杨生岳[1] 闫自强[1] 张瑛[1] 殷和[1] 田忠新[1] 

机构地区：[1]解放军第四医院兰州军区呼吸内科中心,青海西宁810007

出　　处：《临床肺科杂志》2012年第10期1761-1762,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨内源性硫化氢(H2S)与高原地区慢性肺心病肺动脉高压的相关性。方法高原地区慢性肺心病稳定期患者72例和健康对照组40例,分别测定血浆H2S、内皮素-1(ET-1)、平均肺动脉压(mPAP)、动脉血氧分压(PaO2)和二氧化碳分压(PaCO2)。结果肺心病稳定期患者血浆H2S、PaO2水平显著低于健康对照组(均P<0.01),而血浆ET-1、mPAP和PaCO2水平显著高于健康对照组(均P<0.01)。肺心病组患者血浆H2S水平与ET-1、mPAP、PaCO2呈显著负相关(分别为r=-0.718、-0.692、-0.556,均P<0.01),与PaO2呈显著正相关(r=0.583,P<0.01)。结论内源性H2S可能参与了高原肺心病患者肺动脉高压的发生发展,血浆H2S作为一种无创指标监测PAH的严重程度和预后具有一定意义。Objective To observe the correlation between endogenous hydrogen sulfide （H2 S） and pulmonary arteries hyperten- sion （PAH） in patients with chronic cor pulmonale at high altitude （HACCP）. Methods The levels of plasma H2 S, endothelin-1 （ ET- 1 ） , partial pressure of artery blood 02 （ PaO2 ） and partial pressure of in artery blood CO2 （ PaCO2 ） were measured in 72 patients with sta- ble HACCP and 40 health subjects. Results Levels of plasma H2 S and PaO2 were significantly lower in patients with HACCP than those in health subjects （ all P 〈0. O1 ）, and levels of plasma ET-1, mPAP and PaCO2 were significantly higher in patients with HACCP than those in health subjects （all P 〈 0. 01 ）. In patients with HACCP, the plasma H2 S was negatively correlated with plasma ET-1, mPAP and PaCO2 （ r = - 0. 718, - 0. 692, - 0. 556, respectively, all P 〈 0.01 ） , and was positively correlated with PaO2 （ r = 0. 583, P 〈 0. 01 ）. Conclision Endogenous H2S may be involved in the formation and development of PAH in HACCP and may be a noninvasive marker of PAH severity and prognosis of those patients.

关 键 词：硫化氢 慢性肺心病 肺动脉高压 高原 

分 类 号：R541.5[医药卫生—心血管疾病]