胸腺肽α1对AECOPD患者的免疫调节作用  

The immunoregulation effects of thymosin alpha 1 on patients with acute exacerbation of COPD

作　　者：陈淼[1,2] 张红璇[1,2] 詹伟峰[1,2] 林晓军[1,2] 陈纯波[1,2] 

机构地区：[1]广东省人民医院急危重症医学部 [2]广东省医学科学院,广东广州510080

出　　处：《临床肺科杂志》2012年第10期1787-1788,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨胸腺肽α1对AECOPD患者的免疫调节作用。方法 80例AECOPD患者随机分为两组,A组(n=40)仅采用常规方法治疗,B组(n=40)在A组治疗基础上加用胸腺肽α1治疗,同期选择40例健康体检者作为对照组(C组)。观察治疗前后各组血清Th1型细胞因子(IFN-γ)和Th2型细胞因子(IL-4)的表达水平。结果 B组治疗总有效率(90.0%)明显高于A组治疗总有效率(77.5%)(P<0.05);两组治疗前IFN-γ、IL-4表达水平及IL-4/IFN-γ较C组明显增高(P<0.05),治疗后A、B组IFN-γ、IL-4表达水平及IL-4/IFN-γ较治疗前明显下降(P<0.05),且B组下降较A组更为明显(P<0.05)。结论胸腺肽可纠正患者体内Th1/Th2细胞因子平衡紊乱现象,改善COPD患者的免疫系统功能。Objective To investigate the immunoregulation effects of thymosin alpha 1 on patients with acute exacerbation of COPD. Methods 80 patients of acute exacerbation of COPD were randomly divided into two groups, group A （ n = 40） was only treated with routine therapy, and group B （ n = 40） was treated with thymosin alphal on the basis of in A group. At the same time, 40 healthy ea- ses were selected as control group （ group C ）. The expression level of serum Thl cell factors （IFN-γ） and Th2 cell factors （IL4） before and after treatment were observed. Results The total effective rate of B group （90%） was higher than that of A group （77. 5% ） （P 〈 0.05 ）. The expression levels of IFN-γ,, IL-4, and IL-4/IFN-γ, before treatment in the two groups were higher than those of C group （ P 〈 0. 05 ）. The expressions of IFN-γ,, IL-4, and IL-4/IFN-γ/in A, B group after treatment decreased more significantly than those of before treatment （ P 〈 0. 05 ） , and B group decreased more obviously than that of A group （ P 〈 0. 05 ）. Conclusion Thymosin can correct the imbalance phenomenon of Th1/Th2 eytokine in the patients with COPD, and improve the function of immune system of patients with COPD.

关 键 词：胸腺肽 慢性阻塞性肺病 免疫调节 

分 类 号：R563.9[医药卫生—呼吸系统]