支原体肺炎患儿自然杀伤细胞检测及转移因子对该细胞的作用  

Detection of Natural killer cells in children with Mycoplasma pneumoniae pneumonia and effects of transfer factors on Natural killer cells

作　　者：贾文燕[1] 刘继贤[1] 

机构地区：[1]苏州大学附属儿童医院,江苏苏州215003

出　　处：《临床肺科杂志》2012年第10期1798-1799,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨NK细胞与支原体肺炎的关系,并探讨转移因子对NK细胞的作用。方法采用流式细胞仪技术检测60例MPP患儿外周血NK细胞百分率,并以30例健康儿童作对照;60例MPP患儿分为两组,MPP治疗组予以口服阿奇霉素和转移因子进行干预,MPP对照组仅口服阿奇霉素,剂量和疗程相同。结果 MPP组NK细胞百分率明显低于健康对照组(P<0.01);MPP治疗组干预后NK细胞百分率明显升高(P<0.01)。结论 MPP患儿的NK细胞百分率较低;转移因子可提高NK细胞百分率,增强细胞免疫功能。Objective To explore the relationship between Natural killer cells and Mycoplasma pneumoniae pneumonia （MPP） by detecting the Natural killer cells in children with MPP, to learn the main clinical features of MPP and to discuss the effects of transfer factors on Natural killer cells. Methods Collecting sixty eases of MPP children＇s symptoms and chest X-ray performance by consulting history and doing retrospectively analyze. Adopting flow cytometry analysis technology to detect peripheral Natural killer cell percentage of sixty MPP cases, thirty cases of healthy children as control. Sixty MPP children were divided into two groups, MPP treatment group took azithromycin and transfer factors, and the control group only took azithromycin, and dose and duration were the same. Results The per- centage of Natural killer cells in Mycoplasma pneumoniae pneumonia group was lower than that of the control group （P 〈 0.01 ）. The per- centage of Natural killer cells in MPP treatment group after the intervention increased more significantly （ P 〈 0. 01 ）. Conclusion Cough and fever are the major clinical traits of Mycoplasma pneumoniae pneumonia and the chest X-ray changes is mainly for the lobar pneumoni- a. The Natural killer cell＇s function in children with Mycoplasma pneumoniae pneumonia is lower than that in the healthy children, and transfer factors can improve Natural killer cell＇s quantity, enhance cellular immune function.

关 键 词：支原体肺炎 自然杀伤细胞 转移因子 

分 类 号：R725.6[医药卫生—儿科]