铜绿假单胞菌代谢产物体外对白假丝酵母菌等的抑菌活性研究  

In vitro inhibitory activity of the metabolites of Pseudomonas aeruginosa against Candida species

作　　者：秦金喜 李仲兴[2] 杨永昌[3] 袁欣 柏秀菊 石忻罗 

机构地区：[1]徐水县人民医院,河北徐水072550 [2]河北医科大学第二医院,河北石家庄050000 [3]北京军区总医院,北京100730

出　　处：《中国感染控制杂志》2012年第4期257-260,256,共5页Chinese Journal of Infection Control

摘　　要：目的观察铜绿假单胞菌代谢产物对假丝酵母菌属的体外抑菌活性。方法用交叉条带实验方法测定铜绿假单胞菌对54株假丝酵母菌属的体外抑制活性。结果铜绿假单胞菌产生的抗菌物质对白假丝酵母菌及光滑假丝酵母菌的抑菌作用最强,抑菌带最宽。产蓝绿色素的第6株铜绿假单胞菌对白假丝酵母菌和热带假丝酵母菌的抑制率均达100%,产黄绿色素的第8株铜绿假单胞菌对白假丝酵母菌、热带假丝酵母菌和克柔假丝酵母菌的抑制率也均达100%,铜绿假单胞菌产色素菌株的抗真菌活性优于不产色素的菌株。结论铜绿假单胞菌产生的抗菌物质对白假丝酵母菌、光滑假丝酵母菌具有较强的抗真菌活性。Objective To observe in vitro inhibitory activity of the metabolites of Pseudomonas aeruginosa（P.aeruginosa） against Candida spp..Methods In vitro inhibitory activity of P.aeruginosa against 54 Candida spp.isolates was detected by cross-streak assay.Results The metabolites of P.aeruginosa had the strongest inhibitory activity on Candida albicans（C.albicans） and Candida glabratas（C.glabratas）,and produced the widest zone of inhibition.The inhibition rate of aquamarine pigment-producing No.6 P.aeruginosas against C.albicans and Candida tropicalis（C.tropicalis） were both 100%,and the inhibition rate of yellow green pigment-producing No.8 P.aeruginosas against C.albican,C.tropicalis and Candida krusei（C.krusei） were all 100%,too.The pigmented strains were found to have stronger antifungal activity than the unpigmented strains.Conclusion The metabolites of P.aeruginosa has strong antifungal activity against C.albicans and C.glabrata.

关 键 词：铜绿假单胞菌 代谢产物 白假丝酵母菌 光滑假丝酵母菌 克柔假丝酵母菌 热带假丝酵母菌 抑菌活性 

分 类 号：R378.991[医药卫生—病原生物学]